Journal article
Somatic growth outcomes in response to an individualized neonatal sodium supplementation protocol
Journal of perinatology, Vol.45(3), pp.305-311
03/2025
DOI: 10.1038/s41372-024-02141-9
PMCID: PMC12410120
PMID: 39420073
Abstract
Evaluate the impact of a sodium (Na) supplementation protocol based upon urine Na concentration on growth parameters and morbidities.OBJECTIVEEvaluate the impact of a sodium (Na) supplementation protocol based upon urine Na concentration on growth parameters and morbidities.Retrospective cohort study of infants 260/7-336/7 weeks gestational age (GA) cared for before (2012-15, n = 310) and after (2016-20, n = 382) implementation of the protocol. Within- and between-group changes over time were assessed using repeated measures generalized linear models.STUDY DESIGNRetrospective cohort study of infants 260/7-336/7 weeks gestational age (GA) cared for before (2012-15, n = 310) and after (2016-20, n = 382) implementation of the protocol. Within- and between-group changes over time were assessed using repeated measures generalized linear models.For infants 260/7-296/7 weeks GA, utilization of the protocol was associated with increased mean body weight z-score at 8-weeks postnatal age, increased mean head circumference z-score at 16-weeks postnatal age, and decreased time on mechanical ventilation (all p < 0.02). No impact on growth was identified for infants 30-336/7 weeks GA. Incidences of hypertension, hypernatremia, bronchopulmonary dysplasia, necrotizing enterocolitis, and culture positive sepsis were unaffected by the protocol.RESULTSFor infants 260/7-296/7 weeks GA, utilization of the protocol was associated with increased mean body weight z-score at 8-weeks postnatal age, increased mean head circumference z-score at 16-weeks postnatal age, and decreased time on mechanical ventilation (all p < 0.02). No impact on growth was identified for infants 30-336/7 weeks GA. Incidences of hypertension, hypernatremia, bronchopulmonary dysplasia, necrotizing enterocolitis, and culture positive sepsis were unaffected by the protocol.Protocolized Na supplementation is associated with improved growth and reduced time on invasive mechanical ventilation in extremely preterm infants without increasing incidence of morbidities.CONCLUSIONProtocolized Na supplementation is associated with improved growth and reduced time on invasive mechanical ventilation in extremely preterm infants without increasing incidence of morbidities.
Details
- Title: Subtitle
- Somatic growth outcomes in response to an individualized neonatal sodium supplementation protocol
- Creators
- Elliot J Stalter - University of IowaSilvia L Verhofste - Eastern Michigan UniversityJohn M Dagle - University of IowaEmily J Steinbach - University of IowaPatrick Ten EyckLinder Wendt - University of IowaJeffrey L Segar - Medical College of WisconsinLyndsay A Harshman - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Journal of perinatology, Vol.45(3), pp.305-311
- DOI
- 10.1038/s41372-024-02141-9
- PMID
- 39420073
- PMCID
- PMC12410120
- NLM abbreviation
- J Perinatol
- ISSN
- 1476-5543
- eISSN
- 1476-5543
- Publisher
- SPRINGERNATURE
- Grant note
- NIH/NIDDK: R01DK128835, T32DK007690-29, R01DK133197, R01DK133121 NIH CTSA program: UM1TR004403
L.H. receives support from NIH/NIDDK R01DK128835. E.Steinbach receives supportfrom the NIH/NIDDK T32DK007690-29. J.S. receives support from NIH/NIDDK R01DK133197 and NIH/NIDDK R01DK133121. P.T.E. and L.W. receive support fromthe NIH CTSA program grant UM1TR004403. This content is solely the responsibilityof the authors and does not necessarily represent the official views of the NIH.
- Language
- English
- Electronic publication date
- 10/17/2024
- Date published
- 03/2025
- Academic Unit
- Nephrology, Dialysis and Transplantation; Stead Family Department of Pediatrics; Epidemiology; Iowa Neuroscience Institute; Biostatistics; Biology; Radiation Oncology; Neonatology; Design Biostat and Ethics
- Record Identifier
- 9984736749002771
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