Somatostatin Interneurons Facilitate Hippocampal-Prefrontal Synchrony and Prefrontal Spatial Encoding

Atheir I. Abbas; Marina J. M. Sundiang; Britt Henoch; Mitchell P. Morton; Scott S. Bolkan; Alan J. Park; Alexander Z. Harris; Christoph Kellendonk; Joshua A. Gordon

doi:10.1016/j.neuron.2018.09.029

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Somatostatin Interneurons Facilitate Hippocampal-Prefrontal Synchrony and Prefrontal Spatial Encoding

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Somatostatin Interneurons Facilitate Hippocampal-Prefrontal Synchrony and Prefrontal Spatial Encoding

Atheir I. Abbas, Marina J. M. Sundiang, Britt Henoch, Mitchell P. Morton, Scott S. Bolkan, Alan J. Park, Alexander Z. Harris, Christoph Kellendonk and Joshua A. Gordon

Neuron (Cambridge, Mass.), Vol.100(4), pp.926-939.e3

11/21/2018

DOI: 10.1016/j.neuron.2018.09.029

PMCID: PMC6262834

PMID: 30318409

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Abstract

Decreased hippocampal-prefrontal synchrony may mediate cognitive deficits in schizophrenia, but it remains unclear which cells orchestrate this long-range synchrony. Parvalbumin (PV)- and somatostatin (SOM)-expressing interneurons show histological abnormalities in individuals with schizophrenia and are hypothesized to regulate oscillatory synchrony within the prefrontal cortex. To examine the relationship between interneuron function, long-range hi ppocampal-prefrontal synchrony, and cognition, we optogenetically inhibited SOM and PV neurons in the medial prefrontal cortex (mPFC) of mice performing a spatial working memory task while simultaneously recording neural activity in the mPFC and the hippocampus (HPC). We found that inhibiting SOM, but not PV, interneurons during the encoding phase of the task impaired working memory accuracy. This behavioral impairment was associated with decreased hippocampal-prefrontal synchrony and impaired spatial encoding in mPFC neurons. These findings suggest that interneuron dysfunction may contribute to cognitive deficits associated with schizophrenia by disrupting long-range synchrony between the HPC and PFC.

Life Sciences & Biomedicine

Neurosciences

Neurosciences & Neurology

Science & Technology

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Title: Subtitle: Somatostatin Interneurons Facilitate Hippocampal-Prefrontal Synchrony and Prefrontal Spatial Encoding
Creators: Atheir I. Abbas - Columbia University
Marina J. M. Sundiang - New York State Psychiatric Institute
Britt Henoch - New York Psychoanalytic Society and Institute
Mitchell P. Morton - Columbia University
Scott S. Bolkan - Columbia University
Alan J. Park - New York Psychoanalytic Society and Institute
Alexander Z. Harris - Columbia University
Christoph Kellendonk - Columbia University
Joshua A. Gordon - National Institute of Mental Health
Resource Type: Journal article
Publication Details: Neuron (Cambridge, Mass.), Vol.100(4), pp.926-939.e3
DOI: 10.1016/j.neuron.2018.09.029
PMID: 30318409
PMCID: PMC6262834
NLM abbreviation: Neuron
ISSN: 0896-6273
eISSN: 1097-4199
Publisher: Elsevier
Number of pages: 17
Grant note: R01MH096274 / NATIONAL INSTITUTE OF MENTAL HEALTH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Mental Health (NIMH) Irma Hirschl Trust BBRF/NARSAD Young Investigator Grant R01 MH096274; T32 MH018870-29 / NIMH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Mental Health (NIMH) Leon Levy Foundation
Language: English
Date published: 11/21/2018
Academic Unit: Psychological and Brain Sciences
Record Identifier: 9984944741902771

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