Some Forms of cAMP-Mediated Long-Lasting Potentiation Are Associated with Release of BDNF and Nuclear Translocation of Phospho-MAP Kinase

Susan Patterson; Christopher Pittenger; Alexei Morozov; Kelsey C Martin; Heather Scanlin; Carrie Drake; Eric R Kandel

doi:10.1016/S0896-6273(01)00443-3

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Some Forms of cAMP-Mediated Long-Lasting Potentiation Are Associated with Release of BDNF and Nuclear Translocation of Phospho-MAP Kinase

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Some Forms of cAMP-Mediated Long-Lasting Potentiation Are Associated with Release of BDNF and Nuclear Translocation of Phospho-MAP Kinase

Susan Patterson, Christopher Pittenger, Alexei Morozov, Kelsey C Martin, Heather Scanlin, Carrie Drake and Eric R Kandel

Neuron (Cambridge, Mass.), Vol.32(1), pp.123-140

10/11/2001

DOI: 10.1016/S0896-6273(01)00443-3

PMID: 11604144

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Abstract

Long-lasting forms of synaptic plasticity like the late phase of LTP (L-LTP) typically require an elevation of cAMP, the recruitment of the cAMP-dependent protein kinase (PKA), and ultimately the activation of transcription and translation; some forms also require brain-derived neurotrophic factor (BDNF). Both cAMP and BDNF can activate mitogen-activated protein kinase (MAPK/ERK), which also plays a role in LTP. However, little is known about the mechanisms whereby cAMP, BDNF, and MAPK interact. We find that increases in cAMP can rapidly activate the BDNF receptor TrkB and induce BDNF-dependent long-lasting potentiation at the Schaffer collateral-CA1 synapse in hippocampus. Surprisingly, in these BDNF-dependent forms of potentiation, which are also MAPK dependent, TrkB activation is not critical for the activation of MAPK but instead appears to modulate the subcellular distribution and nuclear translocation of the activated MAPK.

Details

Title: Subtitle: Some Forms of cAMP-Mediated Long-Lasting Potentiation Are Associated with Release of BDNF and Nuclear Translocation of Phospho-MAP Kinase
Creators: Susan Patterson - Columbia University
Christopher Pittenger - Columbia University
Alexei Morozov - Columbia University
Kelsey C Martin - University of California, Los Angeles
Heather Scanlin - Columbia University
Carrie Drake - Cornell University
Eric R Kandel - Columbia University
Resource Type: Journal article
Publication Details: Neuron (Cambridge, Mass.), Vol.32(1), pp.123-140
DOI: 10.1016/S0896-6273(01)00443-3
PMID: 11604144
NLM abbreviation: Neuron
ISSN: 0896-6273
eISSN: 1097-4199
Publisher: Elsevier Inc
Language: English
Date published: 10/11/2001
Academic Unit: Iowa Neuroscience Institute
Record Identifier: 9984454746302771

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