Journal article
Sonographic evidence of abnormal tracheal cartilage ring structure in cystic fibrosis
The Laryngoscope, Vol.125(10), pp.2398-2404
10/2015
DOI: 10.1002/lary.25255
PMCID: PMC4578972
PMID: 25827636
Abstract
Tracheal cartilage ring structural abnormalities have been reported in cystic fibrosis (CF) mice and pigs. Whether similar findings are present in humans with CF is unknown. We hypothesized that tracheal cartilage ring shape and size would be different in people with CF.
Tracheal cartilage ring size and shape were measured in adults with (n = 21) and without CF (n = 18).
Ultrasonography was used in human subjects to noninvasively assess tracheal cartilage ring structure in both the sagittal and the transverse planes. Tracheal cartilage ring thickness was also determined from histological sections obtained from newborn non-CF and CF pigs. These values were compared with human data.
Human CF tracheas had a greater width and were less circular in shape compared to non-CF subjects. CF tracheal cartilage rings had a greater midline cross-sectional area and were thicker compared to non-CF rings. Maximal tracheal cartilage ring thickness was also greater in both newborn CF pigs and human adults with CF, compared to non-CF controls.
Our findings demonstrate that structural differences exist in tracheal cartilage rings in adults with CF. Comparison with newborn CF pig data suggests that some of these changes may be congenital in nature.
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Details
- Title: Subtitle
- Sonographic evidence of abnormal tracheal cartilage ring structure in cystic fibrosis
- Creators
- Amit Diwakar - Department of Internal Medicine, University of Iowa Roy J. and Lucille A. Carver College of Medicine, Iowa City, IowaRyan J Adam - Department of Biomedical Engineering, College of Engineering, University of Iowa, Iowa City, IowaAndrew S Michalski - Department of Internal Medicine, University of Iowa Roy J. and Lucille A. Carver College of Medicine, Iowa City, IowaMonelle M Tamegnon - Department of Biostatistics, College of Public Health, University of Iowa, Iowa City, Iowa, U.S.AAnthony J Fischer - Department of Pediatrics, University of Iowa Roy J. and Lucille A. Carver College of Medicine, Iowa City, IowaJan L Launspach - Department of Internal Medicine, University of Iowa Roy J. and Lucille A. Carver College of Medicine, Iowa City, IowaRebecca A Horan - Department of Internal Medicine, University of Iowa Roy J. and Lucille A. Carver College of Medicine, Iowa City, IowaSimon C Kao - Department of Radiology, University of Iowa Roy J. and Lucille A. Carver College of Medicine, Iowa City, IowaKathryn Chaloner - Department of Biostatistics, College of Public Health, University of Iowa, Iowa City, Iowa, U.S.ADavid K Meyerholz - Department of Pathology, University of Iowa Roy J. and Lucille A. Carver College of Medicine, Iowa City, IowaDavid A Stoltz - Department of Biomedical Engineering, College of Engineering, University of Iowa, Iowa City, Iowa
- Resource Type
- Journal article
- Publication Details
- The Laryngoscope, Vol.125(10), pp.2398-2404
- DOI
- 10.1002/lary.25255
- PMID
- 25827636
- PMCID
- PMC4578972
- NLM abbreviation
- Laryngoscope
- ISSN
- 0023-852X
- eISSN
- 1531-4995
- Publisher
- United States
- Grant note
- P30 ES005605 / NIEHS NIH HHS P01 HL091842 / NHLBI NIH HHS HL051670 / NHLBI NIH HHS T32 HL007638 / NHLBI NIH HHS DP2 HL117744 / NCCDPHP CDC HHS HL091842 / NHLBI NIH HHS P01 HL051670 / NHLBI NIH HHS P30 DK054759 / NIDDK NIH HHS DP2 HL117744 / NHLBI NIH HHS
- Language
- English
- Date published
- 10/2015
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Molecular Physiology and Biophysics; Pulmonary, Critical Care, and Occupational Medicine; Pulmonary Medicine; Stead Family Department of Pediatrics; Pathology; Internal Medicine
- Record Identifier
- 9984025441602771
Metrics
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