Sonographic findings in bone marrow transplant patients with symptomatic hepatic venoocclusive disease

M J Sharafuddin; M C Foshager; M Steinbuch; D J Weisdorf; D W Hunter

doi:10.7863/jum.1997.16.9.575

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Sonographic findings in bone marrow transplant patients with symptomatic hepatic venoocclusive disease

Journal article

Peer reviewed

Sonographic findings in bone marrow transplant patients with symptomatic hepatic venoocclusive disease

M J Sharafuddin, M C Foshager, M Steinbuch, D J Weisdorf and D W Hunter

Journal of ultrasound in medicine, Vol.16(9), pp.575-586

09/1997

DOI: 10.7863/jum.1997.16.9.575

PMID: 9321776

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Abstract

Sonographic findings were retrospectively compared between 19 patients with hepatic venoocclusive disease and 23 patients with other common causes of symptomatic liver dysfunction after bone marrow transplantation (14 grafts versus host disease and nine hepatitis). Doppler sonographic examination was available in all patients with venoocclusive disease, in nine of the patients with graft versus host disease, and in three of the patients with hepatitis. The hepatic artery resistive index and the overall flow direction, peak forward and retrograde velocities, and time-averaged mean velocities in the hepatic veins and main portal vein were compared. The portal vein waveform was arbitrarily considered abnormal in the presence of any of the following: highly pulsatile waveform, very low mean velocity, biphasic flow, or flow reversal. Ascites was the most predictive gray scale sonographic finding for venoocclusive disease. Doppler sonographic findings of potential value in the diagnosis of hepatic venoocclusive disease include an abnormal portal vein waveform, resistive index of greater than 0.75, and marked thickening and edema of the gallbladder wall. However, the study is limited by its retrospective nature and reliance primarily on clinical criteria for the diagnosis of venoocclusive disease. Therefore, our findings will need to be verified in a large prospective study.

Hepatic Veno-Occlusive Disease - diagnostic imaging

Hepatitis - diagnostic imaging

Hepatic Veno-Occlusive Disease - etiology

Hepatitis - etiology

Ultrasonography, Doppler

Humans

Portal Vein - physiopathology

Hepatic Artery - physiopathology

Liver Diseases - diagnostic imaging

Graft vs Host Disease - diagnostic imaging

Male

Portal Vein - diagnostic imaging

Hepatic Veins - diagnostic imaging

Liver Diseases - etiology

Blood Flow Velocity

Hepatic Veins - physiopathology

Bone Marrow Transplantation - adverse effects

Adult

Female

Hepatic Artery - diagnostic imaging

Retrospective Studies

Graft vs Host Disease - etiology

Details

Title: Subtitle: Sonographic findings in bone marrow transplant patients with symptomatic hepatic venoocclusive disease
Creators: M J Sharafuddin - Department of Radiology, University of Minnesota Hospital and Clinic, Minneapolis, USA
M C Foshager
M Steinbuch
D J Weisdorf
D W Hunter
Resource Type: Journal article
Publication Details: Journal of ultrasound in medicine, Vol.16(9), pp.575-586
DOI: 10.7863/jum.1997.16.9.575
PMID: 9321776
NLM abbreviation: J Ultrasound Med
ISSN: 0278-4297
eISSN: 1550-9613
Publisher: England
Language: English
Date published: 09/1997
Academic Unit: Radiology; Surgery
Record Identifier: 9984051714502771

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