Journal article
South African GB Virus C Isolates: Interactions between Genotypes 1 and 5 Isolates and HIV
The Journal of infectious diseases, Vol.192(12), pp.2147-2151
12/15/2005
DOI: 10.1086/498170
PMID: 16288381
Abstract
GB virus C (GBV-C) is a common, apparently nonpathogenic human flavivirus that has been associated in some studies with prolonged survival in human immunodeficiency virus (HIV)-positive persons. There are 5 distinct GBV-C genotypes localized to specific geographic regions, and genotype 2 has been previously shown to inhibit HIV replication in vitro in lymphocyte cultures. We identified GBV-C virus isolates representing genotypes 1, 2, and 5 in samples from South African blood donors. GBV-C genotype 1 and 5 isolates replicated in lymphocyte culture, inhibited X4 and R5 HIV-1 isolates, and induced RANTES and stromal-derived factor-1 chemokines in vitro. Thus, African GBV-C genotypes can inhibit HIV replication in vitro
Details
- Title: Subtitle
- South African GB Virus C Isolates: Interactions between Genotypes 1 and 5 Isolates and HIV
- Creators
- Jinhua Xiang - 1Research and Medical Service, Iowa City VA Medical Center, andM. Aslam Sathar - 1Research and Medical Service, Iowa City VA Medical Center, andJames H McLinden - 1Research and Medical Service, Iowa City VA Medical Center, andDonna Klinzman - 1Research and Medical Service, Iowa City VA Medical Center, andQing Chang - 1Research and Medical Service, Iowa City VA Medical Center, andJack T Stapleton - 1Research and Medical Service, Iowa City VA Medical Center, and
- Resource Type
- Journal article
- Publication Details
- The Journal of infectious diseases, Vol.192(12), pp.2147-2151
- DOI
- 10.1086/498170
- PMID
- 16288381
- NLM abbreviation
- J Infect Dis
- ISSN
- 0022-1899
- eISSN
- 1537-6613
- Publisher
- The University of Chicago Press
- Language
- English
- Date published
- 12/15/2005
- Academic Unit
- Microbiology and Immunology; Infectious Diseases; Internal Medicine
- Record Identifier
- 9984094635702771
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