Journal article
Sparse Spectro-Temporal Receptive Fields Based on Multi-Unit and High-Gamma Responses in Human Auditory Cortex
PloS one, Vol.10(9), pp.e0137915-e0137915
2015
DOI: 10.1371/journal.pone.0137915
PMCID: PMC4569421
PMID: 26367010
Abstract
Spectro-Temporal Receptive Fields (STRFs) were estimated from both multi-unit sorted clusters and high-gamma power responses in human auditory cortex. Intracranial electrophysiological recordings were used to measure responses to a random chord sequence of Gammatone stimuli. Traditional methods for estimating STRFs from single-unit recordings, such as spike-triggered-averages, tend to be noisy and are less robust to other response signals such as local field potentials. We present an extension to recently advanced methods for estimating STRFs from generalized linear models (GLM). A new variant of regression using regularization that penalizes non-zero coefficients is described, which results in a sparse solution. The frequency-time structure of the STRF tends toward grouping in different areas of frequency-time and we demonstrate that group sparsity-inducing penalties applied to GLM estimates of STRFs reduces the background noise while preserving the complex internal structure. The contribution of local spiking activity to the high-gamma power signal was factored out of the STRF using the GLM method, and this contribution was significant in 85 percent of the cases. Although the GLM methods have been used to estimate STRFs in animals, this study examines the detailed structure directly from auditory cortex in the awake human brain. We used this approach to identify an abrupt change in the best frequency of estimated STRFs along posteromedial-to-anterolateral recording locations along the long axis of Heschl's gyrus. This change correlates well with a proposed transition from core to non-core auditory fields previously identified using the temporal response properties of Heschl's gyrus recordings elicited by click-train stimuli.
Details
- Title: Subtitle
- Sparse Spectro-Temporal Receptive Fields Based on Multi-Unit and High-Gamma Responses in Human Auditory Cortex
- Creators
- Rick L Jenison - Department of Psychology, University of Wisconsin Madison, Madison, Wisconsin, United States of AmericaRichard A Reale - Department of Psychology, University of Wisconsin Madison, Madison, Wisconsin, United States of America; Department of Neurosurgery, University of Iowa, Iowa City, Iowa, United States of AmericaAmanda L Armstrong - Department of Psychology, University of Wisconsin Madison, Madison, Wisconsin, United States of AmericaHiroyuki Oya - Department of Neurosurgery, University of Iowa, Iowa City, Iowa, United States of AmericaHiroto Kawasaki - Department of Neurosurgery, University of Iowa, Iowa City, Iowa, United States of AmericaMatthew A Howard III - Department of Neurosurgery, University of Iowa, Iowa City, Iowa, United States of America
- Resource Type
- Journal article
- Publication Details
- PloS one, Vol.10(9), pp.e0137915-e0137915
- DOI
- 10.1371/journal.pone.0137915
- PMID
- 26367010
- PMCID
- PMC4569421
- NLM abbreviation
- PLoS One
- ISSN
- 1932-6203
- eISSN
- 1932-6203
- Publisher
- Public Library of Science; United States
- Grant note
- R01 DC004290 / NIDCD NIH HHS M01RR59 / NCRR NIH HHS R01DC04290 / NIDCD NIH HHS
- Language
- English
- Date published
- 2015
- Academic Unit
- Neurology; Iowa Neuroscience Institute; Neurosurgery; Otolaryngology
- Record Identifier
- 9984013203502771
Metrics
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