Journal article
Spatial and temporal heterogeneity of left ventricular perfusion in awake dogs
The American heart journal, Vol.94(6), pp.748-754
1977
DOI: 10.1016/S0002-8703(77)80216-0
PMID: 920583
Abstract
The purpose of this investigation was to ascertain if spatial and temporal heterogeneity of myocardial blood flow occurred in awake dogs under basal conditions. Myocardial perfusion was assessed by injecting differently labeled 15±5 μ or 7 to 10 μ microspheres into the left atrium. Spatial heterogeneity of perfusion was determined in 24 awake dogs by analyzing the distribution of perfusion to 96 segments of the left ventricle. Spatial heterogeneity expressed as the relative dispersion of the segmental perfusion averaged 21.4±SE 1.5 per cent. The variation in segmental perfusion due to the microsphere technique was assessed by injecting three or four batches of microspheres simultaneously in six of the dogs. Temporal heterogeneity was assessed by sequentially injecting three or four batches of microspheres, at 1 minute intervals, in six other dogs while left atrial pressure, arterial pressure, heart rate, and left ventricular perfusion were held constant. The average range of segmental perfusion was greater in the sequentially injected dogs than in the simultaneously injected dogs (26.0±SE 2.7 per cent vs 16.3±SE 1.7 per cent, respectively [p<0.01]). Thus, this study indicates that spatial and temporal heterogeneity of left ventricular perfusion is present in awake dogs studied under basal conditions.
Details
- Title: Subtitle
- Spatial and temporal heterogeneity of left ventricular perfusion in awake dogs
- Creators
- Melvin L MarcusRichard E KerberJames C ErhardtHerman L FalsettiDeana M DavisFrancois M AbboudPaul B McKayOscar Y Lim
- Resource Type
- Journal article
- Publication Details
- The American heart journal, Vol.94(6), pp.748-754
- Publisher
- Mosby, Inc
- DOI
- 10.1016/S0002-8703(77)80216-0
- PMID
- 920583
- ISSN
- 0002-8703
- eISSN
- 1097-6744
- Language
- English
- Date published
- 1977
- Academic Unit
- Molecular Physiology and Biophysics; Cardiovascular Medicine; Fraternal Order of Eagles Diabetes Research Center; Internal Medicine
- Record Identifier
- 9984025425202771
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