Spatial genetic structure of 2009 H1N1 pandemic influenza established as a result of interaction with human populations in mainland China

Seungwon Kim; Margaret Carrel; Andrew Kitchen

doi:10.1371/journal.pone.0284716

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Spatial genetic structure of 2009 H1N1 pandemic influenza established as a result of interaction with human populations in mainland China

Journal article

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Spatial genetic structure of 2009 H1N1 pandemic influenza established as a result of interaction with human populations in mainland China

Seungwon Kim, Margaret Carrel and Andrew Kitchen

PloS one, Vol.18(5), p.e0284716

05/17/2023

DOI: 10.1371/journal.pone.0284716

PMCID: PMC10191359

PMID: 37196010

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Abstract

Identifying the spatial patterns of genetic structure of influenza A viruses is a key factor for understanding their spread and evolutionary dynamics. In this study, we used phylogenetic and Bayesian clustering analyses of genetic sequences of the A/H1N1pdm09 virus with district-level locations in mainland China to investigate the spatial genetic structure of the A/H1N1pdm09 virus across human population landscapes. Positive correlation between geographic and genetic distances indicates high degrees of genetic similarity among viruses within small geographic regions but broad-scale genetic differentiation, implying that local viral circulation was a more important driver in the formation of the spatial genetic structure of the A/H1N1pdm09 virus than even, countrywide viral mixing and gene flow. Geographic heterogeneity in the distribution of genetic subpopulations of A/H1N1pdm09 virus in mainland China indicates both local to local transmission as well as broad-range viral migration. This combination of both local and global structure suggests that both small-scale and large-scale population circulation in China is responsible for viral genetic structure. Our study provides implications for understanding the evolution and spread of A/H1N1pdm09 virus across the population landscape of mainland China, which can inform disease control strategies for future pandemics.

Bayes Theorem

China - epidemiology

Humans

Influenza A Virus, H1N1 Subtype - genetics

Influenza, Human - epidemiology

Influenza, Human - genetics

Phylogeny

Details

Title: Subtitle: Spatial genetic structure of 2009 H1N1 pandemic influenza established as a result of interaction with human populations in mainland China
Creators: Seungwon Kim - Department of Geographical and Sustainability Sciences, University of Iowa, Iowa City, Iowa, United States of America
Margaret Carrel - University of Iowa
Andrew Kitchen - University of Iowa
Resource Type: Journal article
Publication Details: PloS one, Vol.18(5), p.e0284716
DOI: 10.1371/journal.pone.0284716
PMID: 37196010
PMCID: PMC10191359
NLM abbreviation: PLoS One
ISSN: 1932-6203
eISSN: 1932-6203
Language: English
Date published: 05/17/2023
Academic Unit: Anthropology; International Programs; Epidemiology; Interdisciplinary Programs; Geographical and Sustainability Sciences; Internal Medicine
Record Identifier: 9984413067402771

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