Journal article
Spatial reconstruction by patients with hippocampal damage is dominated by relational memory errors
Hippocampus, Vol.23(7), pp.570-580
07/2013
DOI: 10.1002/hipo.22115
PMCID: PMC3697762
PMID: 23418096
Abstract
Hippocampal damage causes profound yet circumscribed memory impairment across diverse stimulus types and testing formats. Here, within a single test format involving a single class of stimuli, we identified different performance errors to better characterize the specifics of the underlying deficit. The task involved study and reconstruction of object arrays across brief retention intervals. The most striking feature of patients' with hippocampal damage performance was that they tended to reverse the relative positions of item pairs within arrays of any size, effectively "swapping" pairs of objects. These "swap errors" were the primary error type in amnesia, almost never occurred in healthy comparison participants, and actually contributed to poor performance on more traditional metrics (such as distance between studied and reconstructed location). Patients made swap errors even in trials involving only a single pair of objects. The selectivity and severity of this particular deficit creates serious challenges for theories of memory and hippocampus.
Details
- Title: Subtitle
- Spatial reconstruction by patients with hippocampal damage is dominated by relational memory errors
- Creators
- Patrick D Watson - Beckman Institute for Advanced Science and Technology, Department of Psychology and Interdepartmental Neuroscience Program, University of Illinois Urbana-Champaign, Urbana, IL, USA. pwatson1@illinois.eduJoel L VossDavid E WarrenDaniel TranelNeal J Cohen
- Resource Type
- Journal article
- Publication Details
- Hippocampus, Vol.23(7), pp.570-580
- DOI
- 10.1002/hipo.22115
- PMID
- 23418096
- PMCID
- PMC3697762
- NLM abbreviation
- Hippocampus
- ISSN
- 1050-9631
- eISSN
- 1098-1063
- Publisher
- United States
- Grant note
- P50 NS019632 / NINDS NIH HHS R01-MH062500 / NIMH NIH HHS M01 RR000059 / NCRR NIH HHS R00 NS069788 / NINDS NIH HHS K99 NS069788 / NINDS NIH HHS P50-NS19632 / NINDS NIH HHS R01 MH062500 / NIMH NIH HHS K99/R00-NS069788 / NINDS NIH HHS
- Language
- English
- Date published
- 07/2013
- Academic Unit
- Neurology; Psychological and Brain Sciences; Iowa Neuroscience Institute
- Record Identifier
- 9984002579402771
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