Specific Dopaminergic Neurons for the Formation of Labile Aversive Memory

Yoshinori Aso; Igor Siwanowicz; Lasse Bräcker; Kei Ito; Toshihiro Kitamoto; Hiromu Tanimoto

doi:10.1016/j.cub.2010.06.048

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Specific Dopaminergic Neurons for the Formation of Labile Aversive Memory

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Specific Dopaminergic Neurons for the Formation of Labile Aversive Memory

Yoshinori Aso, Igor Siwanowicz, Lasse Bräcker, Kei Ito, Toshihiro Kitamoto and Hiromu Tanimoto

Current biology, Vol.20(16), pp.1445-1451

08/24/2010

DOI: 10.1016/j.cub.2010.06.048

PMCID: PMC2929706

PMID: 20637624

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Abstract

A paired presentation of an odor and electric shock induces aversive odor memory in Drosophila melanogaster [1, 2]. Electric shock reinforcement is mediated by dopaminergic neurons [3–5], and it converges with the odor signal in the mushroom body (MB) [2, 6–8]. Dopamine is synthesized in ∼280 neurons that form distinct cell clusters [9–11] and is involved in a variety of brain functions [9, 12–20]. Recently, one of the dopaminergic clusters (PPL1) that includes MB-projecting neurons was shown to signal reinforcement for aversive odor memory [21]. As each dopaminergic cluster contains multiple types of neurons with different projections and physiological characteristics [11, 20], functional understanding of the circuit for aversive memory requires cellular identification. Here, we show that MB-M3, a specific type of dopaminergic neurons in the PAM cluster, is preferentially required for the formation of labile memory. Strikingly, flies formed significant aversive odor memory without electric shock when MB-M3 was selectively stimulated together with odor presentation. In addition, we identified another type of dopaminergic neurons in the PPL1 cluster, MB-MP1, which can induce aversive odor memory. As MB-M3 and MB-MP1 target the distinct subdomains of the MB, these reinforcement circuits might induce different forms of aversive memory in spatially segregated synapses in the MB. [Display omitted] ► Individual dopaminergic neurons are activated or suppressed by therrmogenetics ► MB-M3 is preferentially required for labile olfactory memory ► Local stimulation in the mushroom body is sufficient for aversive memory formation ► Multiple types of dopaminergic neurons mediate aversive reinforcement

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Title: Subtitle: Specific Dopaminergic Neurons for the Formation of Labile Aversive Memory
Creators: Yoshinori Aso - Max-Planck-Institut für Neurobiologie, Am Klopferspitz 18, D-82152 Martinsried, Germany
Igor Siwanowicz - Max-Planck-Institut für Neurobiologie, Am Klopferspitz 18, D-82152 Martinsried, Germany
Lasse Bräcker - Max-Planck-Institut für Neurobiologie, Am Klopferspitz 18, D-82152 Martinsried, Germany
Kei Ito - Institute of Molecular and Cellular Biosciences, The University of Tokyo, Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan
Toshihiro Kitamoto - Department of Anesthesia and Interdisciplinary Programs in Genetics and Neuroscience, University of Iowa, 51 Newton Road, Iowa City, IA 52242, USA
Hiromu Tanimoto - Max-Planck-Institut für Neurobiologie, Am Klopferspitz 18, D-82152 Martinsried, Germany
Resource Type: Journal article
Publication Details: Current biology, Vol.20(16), pp.1445-1451
Publisher: Elsevier Inc
DOI: 10.1016/j.cub.2010.06.048
PMID: 20637624
PMCID: PMC2929706
ISSN: 0960-9822
eISSN: 1879-0445
Language: English
Date published: 08/24/2010
Academic Unit: Iowa Neuroscience Institute; Anesthesia; Neuroscience and Pharmacology
Record Identifier: 9984007157002771

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