Journal article
Specific and nonspecific NK cell activation during virus infection
Nature immunology, Vol.2(10), pp.951-956
10/2001
DOI: 10.1038/ni714
PMID: 11550009
Abstract
The natural killer (NK) cell activation receptor Ly49H is required for resistance to murine cytomegalovirus (MCMV). We show here that NK cell proliferation and production of interferon-γ (IFN-γ) was not dependent on Ly49H expression during early MCMV infection. During a later phase of infection, however, Ly49H+ NK cells selectively proliferated and this expansion was blocked by anti-Ly49H administration. With vaccinia virus infection, neither the early nor late phase of NK cell proliferation was selective for Ly49H+ NK cells. These findings indicated that Ly49H+ NK cells were specifically activated by MCMV and that MCMV infection was characterized by nonspecific and specific phases of NK cell activation in vivo.
Details
- Title: Subtitle
- Specific and nonspecific NK cell activation during virus infection
- Creators
- Wayne M Yokoyama - Washington University in St. LouisAyotunde O Dokun - Howard Hughes Medical InstituteSungjin Kim - Howard Hughes Medical Institute, Rheumatology Division, Departments of Medicine and Pathology and Immunology, Washington University School of MedicineHamish R.C Smith - Washington University in St. LouisHyun-Seok P Kang - Howard Hughes Medical Institute, Rheumatology Division, Departments of Medicine and Pathology and Immunology, Washington University School of MedicineDortha T Chu - Washington University in St. Louis
- Resource Type
- Journal article
- Publication Details
- Nature immunology, Vol.2(10), pp.951-956
- DOI
- 10.1038/ni714
- PMID
- 11550009
- NLM abbreviation
- Nat Immunol
- ISSN
- 1529-2908
- eISSN
- 1529-2916
- Language
- English
- Date published
- 10/2001
- Academic Unit
- Molecular Physiology and Biophysics; Fraternal Order of Eagles Diabetes Research Center; Endocrinology and Metabolism; Internal Medicine
- Record Identifier
- 9984297494602771
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