Journal article
Specific immunity to listeria monocytogenes in the absence of IFNγ
Immunity (Cambridge, Mass.), Vol.3(1), pp.109-117
1995
DOI: 10.1016/1074-7613(95)90163-9
PMID: 7621071
Abstract
Cytokine and cytokine receptor gene knockout mice provide powerful experimental systems to characterize the functions of these molecules in resistance to infectious disease. Such mice may also provide unique models of immune deficiency to learn whether manipulation of the Immune response can overcome the specific dysfunction. We demonstrate that resistance of IFNγ gene knockout (GKO
−/−) mice to the intracellular bacterium Listerla monocytogenes is severely impaired compared with wild-type mice. However, immunization of GKO
−/− mice with an attenuated L. monocytogenes strain generates antigen-specific CD8 T cell responses that can transfer Immunity to naive hosts. Furthermore, vaccinated GKO
−/− mice themselves exhibit 20,000-fold increased resistance to challenge with virulent L. monocytogenes and this resistance appears to be CD8 T cell mediated. These studies demonstrate that vaccination-Induced Immunity can overcome the absence of a cytokine that is critical for resistance to acute infection.
Details
- Title: Subtitle
- Specific immunity to listeria monocytogenes in the absence of IFNγ
- Creators
- John T Harty - Department of Microbiology University of Iowa Iowa City, Iowa 52242, USAMichael J Bevant - Howard Hughes Medical Institute Department of Immunology University of Washington Seattle, Washington 98195, USA
- Resource Type
- Journal article
- Publication Details
- Immunity (Cambridge, Mass.), Vol.3(1), pp.109-117
- Publisher
- Elsevier Inc
- DOI
- 10.1016/1074-7613(95)90163-9
- PMID
- 7621071
- ISSN
- 1074-7613
- eISSN
- 1097-4180
- Language
- English
- Date published
- 1995
- Academic Unit
- Pathology
- Record Identifier
- 9984047650702771
Metrics
14 Record Views