Journal article
Specific insulin-like growth factor (IGF) I- and II-binding sites on rat granulosa cells: Relation to IGF action
Endocrinology (Philadelphia), Vol.119(5), pp.2155-2162
01/01/1986
DOI: 10.1210/endo-119-5-2155
PMID: 2945713
Abstract
Although insulin-like growth factor-I (IGF-I) and insulin have been shown to augment rat granulosa cell differentiation, their mechanism(s) of action has not yet been elucidated. In the present study, the authors have examined granulosa cells obtained from immature hypophysectomized estrogen-treated rats for specific IGF-binding sites that might mediate the effects of the insulin-like peptides. Results demonstrate a biological action of synthetic IGF-II in granulosa cells and further show a novel insulin effect, enhancement of LH/hCG receptor induction. Since IGF-I appears to be the most biologically potent peptide, it is likely to be the most important insulin-like peptide involved in granulosa cell differentiation in vivo.
Details
- Title: Subtitle
- Specific insulin-like growth factor (IGF) I- and II-binding sites on rat granulosa cells: Relation to IGF action
- Creators
- B DavorenB KassonC H LiAJW Hsueh
- Resource Type
- Journal article
- Publication Details
- Endocrinology (Philadelphia), Vol.119(5), pp.2155-2162
- DOI
- 10.1210/endo-119-5-2155
- PMID
- 2945713
- ISSN
- 0013-7227
- eISSN
- 1945-7170
- Language
- English
- Date published
- 01/01/1986
- Academic Unit
- Neuroscience and Pharmacology
- Record Identifier
- 9984303854602771
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