Journal article
Specific microbial ratio in the gut microbiome is associated with multiple sclerosis
Proceedings of the National Academy of Sciences - PNAS, Vol.122(10), p.e2413953122
03/03/2025
DOI: 10.1073/pnas.2413953122
PMCID: PMC11912405
PMID: 40030030
Abstract
Gut microbiota dysbiosis is associated with multiple sclerosis (MS), but the causal relationship between specific gut bacteria and MS pathogenesis remains poorly understood. Therefore, we profiled the stool microbiome of people with MS (PwMS) and healthy controls (HC) using shotgun metagenomic sequencing. PwMS showed a distinct microbiome compared to HC, with
(
) and
species as drivers of microbial communities in HC and PwMS, respectively. Administration of MS-driving
species (
) to mice resulted in increased levels of gut inflammatory markers and altered microbiota with increased capacity to induce proinflammatory cytokines. Utilizing experimental autoimmune encephalomyelitis (EAE), an animal model of MS, we identified a lower gut
to
ratio as a hallmark of the disease.
-administered mice also showed a lower
to
ratio pre-EAE induction which correlated with increased disease severity post-EAE induction. The importance of the
to
ratio at the species level, lower
to
(
), was validated in our MS cohort and a large International Multiple Sclerosis Microbiome Study. Thus, our findings highlight the
ratio as a potential gut microbial marker in PwMS, opening avenues for microbiome-based diagnosis, prognosis, and therapy in MS.
Details
- Title: Subtitle
- Specific microbial ratio in the gut microbiome is associated with multiple sclerosis
- Creators
- Sudeep Ghimire - University of IowaPeter C Lehman - University of IowaLeeann S Aguilar Meza - Microbiome Core, University of Iowa, Iowa City, IA 52242Shailesh K Shahi - University of IowaJemmie Hoang - University of IowaHeena Olalde - University of Iowa Hospitals and ClinicsMishelle Paullus - University of Iowa Hospitals and ClinicsCatherine Cherwin - University of IowaKai Wang - University of IowaChristine Gill - University of Iowa Hospitals and ClinicsTracey Cho - University of Iowa Hospitals and ClinicsAshutosh K Mangalam - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Proceedings of the National Academy of Sciences - PNAS, Vol.122(10), p.e2413953122
- DOI
- 10.1073/pnas.2413953122
- PMID
- 40030030
- PMCID
- PMC11912405
- NLM abbreviation
- Proc Natl Acad Sci U S A
- ISSN
- 0027-8424
- eISSN
- 1091-6490
- Publisher
- NATL ACAD SCIENCES
- Grant note
- P30 ES005605 / NIEHS NIH HHS R01AI137075 / HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) 1I01CX002212 / U.S. Department of Veterans Affairs (VA) T32AI007260 / HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID)
- Language
- English
- Date published
- 03/03/2025
- Academic Unit
- Neurology; Pathology; Iowa Neuroscience Institute; Biostatistics; Nursing
- Record Identifier
- 9984799682102771
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