Journal article
Specific recognition of apoptotic cells reveals a ubiquitous and unconventional innate immunity
The Journal of biological chemistry, Vol.281(29), pp.20055-20067
07/21/2006
DOI: 10.1074/jbc.M603920200
PMID: 16707494
Abstract
The purpose of physiological cell death is the noninflammatory clearance of cells that have become inappropriate or nonfunctional. Consistent with this function, the recognition of apoptotic cells by professional phagocytes, including macrophages and dendritic cells, triggers a set of potent anti-inflammatory responses manifest on multiple levels. The immediate-early inhibition of proinflammatory cytokine gene transcription in the phagocyte is a proximate consequence of recognition of the apoptotic corpse, independent of subsequent engulfment and soluble factor involvement. Here, we show that recognition is linked to a characteristic signature of responses, including MAPK signaling events and the ablation of proinflammatory transcription and cytokine secretion. Specific recognition and response occurs without regard to the origin (species, tissue type, or suicidal stimulus) of the apoptotic cell and does not involve Toll-like receptor signaling. These features mark this as an innate immunity fundamentally distinct from the discrimination of "self" versus "other" considered to be the hallmark of conventional immunity. This profound unconventional innate immune discrimination of effete from live cells is as ubiquitous as apoptotic cell death itself, manifest by professional and nonprofessional phagocytes and nonphagocytic cell types alike. Innate apoptotic immunity provides an intrinsic anti-inflammatory circuit that attenuates proinflammatory responses dynamically and may act systemically as a powerful physiological regulator of immunity.
Details
- Title: Subtitle
- Specific recognition of apoptotic cells reveals a ubiquitous and unconventional innate immunity
- Creators
- Marija Cvetanovic - University of Illinois ChicagoJustin E Mitchell - University of Illinois ChicagoVimal Patel - University of Illinois ChicagoBenjamin S Avner - University of Illinois ChicagoYan Su - Loyola University ChicagoPaul T van der Saag - Hubrecht Institute for Developmental Biology and Stem Cell ResearchPamela L Witte - Loyola University ChicagoStefano Fiore - University of Illinois ChicagoJerrold S Levine - University of Illinois ChicagoDavid S Ucker - University of Illinois Chicago
- Resource Type
- Journal article
- Publication Details
- The Journal of biological chemistry, Vol.281(29), pp.20055-20067
- DOI
- 10.1074/jbc.M603920200
- PMID
- 16707494
- NLM abbreviation
- J Biol Chem
- ISSN
- 0021-9258
- eISSN
- 1083-351X
- Grant note
- AG024234 / NIA NIH HHS DK59793 / NIDDK NIH HHS T32 AI007343 / NIAID NIH HHS
- Language
- English
- Date published
- 07/21/2006
- Academic Unit
- Internal Medicine
- Record Identifier
- 9985237609002771
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