Journal article
Specificity of human natural killer cells in limiting dilution culture for determinants of herpes simplex virus type 1 glycoproteins
Journal of virology, Vol.57(1), pp.294-300
01/1986
DOI: 10.1128/JVI.57.1.294-300.1986
PMCID: PMC252726
PMID: 2416952
Abstract
The frequency and specificity of human cells with natural killer (NK) cytotoxic activity for herpes simplex virus type 1 (HSV-1)-infected targets was measured by limiting dilution culture. The frequency of NK cell precursors (NK-p) reactive with HSV-1-infected cells was 2- to 11-fold higher than that of NK-p reactive with mock-infected cells. The frequency of NK-p reactive with infected target cells lacking viral glycoprotein C or presenting an antigenically altered glycoprotein B was approximately twofold lower than that with wild-type virus-infected cells. Specificity analysis demonstrated that NK cells with a high statistical probability of being monoclonal were reactive with either glycoprotein B or C. These results provide the first evidence that cells with human NK activity possess clonal specificity for HSV-1-infected target cells.
Details
- Title: Subtitle
- Specificity of human natural killer cells in limiting dilution culture for determinants of herpes simplex virus type 1 glycoproteins
- Creators
- Gail Abendroth BishopGunther KümelStanley A SchwartzJoseph C Glorioso
- Resource Type
- Journal article
- Publication Details
- Journal of virology, Vol.57(1), pp.294-300
- Publisher
- United States
- DOI
- 10.1128/JVI.57.1.294-300.1986
- PMID
- 2416952
- PMCID
- PMC252726
- ISSN
- 0022-538X
- eISSN
- 1098-5514
- Grant note
- AI-17900 / NIAID NIH HHS AI-18228 / NIAID NIH HHS AI-16216 / NIAID NIH HHS
- Language
- English
- Date published
- 01/1986
- Academic Unit
- Microbiology and Immunology; President
- Record Identifier
- 9984001156202771
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