Journal article
Spectral analyses of systolic blood pressure and heart rate variability and their association with cognitive performance in elderly hypertensive subjects
Journal of human hypertension, Vol.29(8), pp.488-494
08/2015
DOI: 10.1038/jhh.2014.119
PMID: 25518896
Abstract
Systolic hypertension is associated with cognitive decline in the elderly. Altered blood pressure (BP) variability is a possible mechanism of reduced cognitive performance in elderly hypertensives. We hypothesized that altered beat-to-beat systolic BP variability is associated with reduced global cognitive performance in elderly hypertensive subjects. In exploratory analyses, we also studied the correlation between diverse discrete cognitive domains and indices of systolic BP and heart rate variability. Disproving our initial hypothesis, we have shown that hypertension and low education, but not indices of systolic BP and heart rate variability, were independent predictors of lower global cognitive performance. However, exploratory analyses showed that the systolic BP variability in semi-upright position was an independent predictor of matrix reasoning (B = 0.08 ± .03, P-value = 0.005), whereas heart rate variability in semi-upright position was an independent predictor of the executive function score (B = -6.36 ± 2.55, P-value = 0.02). We conclude that myogenic vascular and sympathetic modulation of systolic BP do not contribute to reduced global cognitive performance in treated hypertensive subjects. Nevertheless, our results suggest that both systolic BP and heart rate variability might be associated with modulation of frontal lobe cognitive domains, such as executive function and matrix reasoning.
Details
- Title: Subtitle
- Spectral analyses of systolic blood pressure and heart rate variability and their association with cognitive performance in elderly hypertensive subjects
- Creators
- W B Santos - Department of Clinical Medicine, State University of Rio de Janeiro, Rio de Janeiro, BrazilJ M D Matoso - Department of Clinical Medicine, State University of Rio de Janeiro, Rio de Janeiro, BrazilM Maltez - Physical Activity and Health Promotion Laboratory, State University of Rio de Janeiro, Rio de Janeiro, BrazilT Gonçalves - Department of Physiology and Pharmacology, Fluminense Federal University, Rio de Janeiro, BrazilM Casanova - Department of Clinical Medicine, State University of Rio de Janeiro, Rio de Janeiro, BrazilI F H Moreira - Department of Clinical Medicine, State University of Rio de Janeiro, Rio de Janeiro, BrazilR A Lourenço - Department of Clinical Medicine, State University of Rio de Janeiro, Rio de Janeiro, BrazilW D Monteiro - Physical Activity and Health Promotion Laboratory, State University of Rio de Janeiro, Rio de Janeiro, BrazilP T V Farinatti - Physical Activity and Health Promotion Laboratory, State University of Rio de Janeiro, Rio de Janeiro, BrazilP P Soares - Department of Physiology and Pharmacology, Fluminense Federal University, Rio de Janeiro, BrazilW Oigman - Department of Clinical Medicine, State University of Rio de Janeiro, Rio de Janeiro, BrazilM F T Neves - Department of Clinical Medicine, State University of Rio de Janeiro, Rio de Janeiro, BrazilM L G Correia - Department of Clinical Medicine, State University of Rio de Janeiro, Rio de Janeiro, Brazil
- Resource Type
- Journal article
- Publication Details
- Journal of human hypertension, Vol.29(8), pp.488-494
- DOI
- 10.1038/jhh.2014.119
- PMID
- 25518896
- ISSN
- 0950-9240
- eISSN
- 1476-5527
- Language
- English
- Date published
- 08/2015
- Academic Unit
- Endocrinology and Metabolism; Internal Medicine
- Record Identifier
- 9984094371702771
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