Journal article
Spectroscopic Monitoring and Modeling Drug Dissolution for Undergraduate Chemistry Curriculum
Journal of chemical education, Vol.101(4), pp.1648-1655
04/09/2024
DOI: 10.1021/acs.jchemed.2c00707
PMCID: PMC11008090
PMID: 38617817
Appears in UI Libraries Support Open Access
Abstract
The pharmaceutical and medicine manufacturing industry has become the largest industrial sector for the employment of chemists, indicating a need for experiments with a pharmaceutical sciences context in the undergraduate chemistry curriculum. In the pharmaceutical industry, testing drug dissolution is a key analytical task for solid oral dosage forms that is performed in different phases of drug development to test the release behavior of new formulations, ensure consistency between manufacturing lots, and help predict the in vivo absorption of the drug substance after administration. However, there are a limited number of laboratory experiments in dissolution testing developed for the undergraduate chemistry curriculum. To help students obtain hands-on experience in dissolution testing, a protocol has been developed for an undergraduate chemistry laboratory course for students to build a dissolution apparatus, monitor dissolution processes, model the dissolution to extract kinetic parameters, and evaluate the consistency between dissolution curves with FDA regulated methods. Students successfully collected dissolution curves and completed the modeling analysis with nonlinear least-squares fitting. The designed dissolution protocol has been evaluated to have consistency and reproducibility to be implemented in the undergraduate chemistry laboratory curriculum.
Details
- Title: Subtitle
- Spectroscopic Monitoring and Modeling Drug Dissolution for Undergraduate Chemistry Curriculum
- Creators
- Chengxuan Guo - University of IowaNicole Wendel - University of IowaAlly Lee - Chadwick International SchoolShonda Monette - University of IowaBrian Morrison - University of IowaDominic Frisbie - University of IowaEarlene Erbe - University of IowaRenée S. Cole - University of Iowa, ChemistryM Lei Geng - University of Iowa, Chemistry
- Resource Type
- Journal article
- Publication Details
- Journal of chemical education, Vol.101(4), pp.1648-1655
- DOI
- 10.1021/acs.jchemed.2c00707
- PMID
- 38617817
- PMCID
- PMC11008090
- NLM abbreviation
- J Chem Educ
- ISSN
- 0021-9584
- eISSN
- 1938-1328
- Publisher
- American Chemical Society
- Grant note
- DOI: 10.13039/100000001, name: National Science Foundation, award: 0911691
- Language
- English
- Date published
- 04/09/2024
- Academic Unit
- Chemistry
- Record Identifier
- 9984585957402771
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