Journal article
Spectrum of hemostatic derangements, in Budd-Chiari syndrome
Indian journal of gastroenterology, Vol.22(2), pp.59-60
03/2003
PMID: 12696825
Abstract
Hemostatic abnormalities have been reported in various hepatocellular diseases. We evaluated the hemostatic functions in patients with Budd-Chiari syndrome.
Biochemical liver function tests, and measurement of prothrombin time, activated partial thromboplastin time, and plasma levels of anti-thrombin III (antigen) and activity of protein C were done in 36 patients with Budd-Chiari syndrome.
Liver biochemistry was abnormal in 34 patients. Plasma prothrombin time and activated partial thromboplastin time were prolonged in 17 (47%) and 23 (64%) patients, respectively. Antithrombin III antigen levels and protein C activity were reduced in 15 (50%) and 25 (83%) patients, respectively, among the 30 patients studied. Albumin levels showed significant correlation with coagulation test results, levels of anti-thrombin-III, and protein C activity.
Hepatic synthesis of coagulation factors and anticoagulants is reduced in Budd-Chiari syndrome; this may play a role in recurrence of thrombosis.
Details
- Title: Subtitle
- Spectrum of hemostatic derangements, in Budd-Chiari syndrome
- Creators
- Hara Prasad Pati - Department of Hematology, All India Institute of Medical Sciences, New Delhi 110 029. harappati@yahoo.comSanjana DayalAmita SrivastavaGirish Kumar PandeSubrat Kumar Acharya
- Resource Type
- Journal article
- Publication Details
- Indian journal of gastroenterology, Vol.22(2), pp.59-60
- Publisher
- India
- PMID
- 12696825
- ISSN
- 0254-8860
- eISSN
- 0975-0711
- Language
- English
- Date published
- 03/2003
- Academic Unit
- Hematology, Oncology, and Blood & Marrow Transplantation; Iowa Neuroscience Institute; Fraternal Order of Eagles Diabetes Research Center; Internal Medicine
- Record Identifier
- 9984065476502771
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