Journal article
Spinal afferent neurons: emerging regulators of energy balance and metabolism
Frontiers in molecular neuroscience, Vol.17, 1479876
11/08/2024
DOI: 10.3389/fnmol.2024.1479876
PMCID: PMC11583444
PMID: 39582948
Abstract
Recent advancements in neurophysiology have challenged the long-held paradigm that vagal afferents serve as the primary conduits for physiological signals governing food intake and energy expenditure. An expanding body of evidence now illuminates the critical role of spinal afferent neurons in these processes, necessitating a reevaluation of our understanding of energy homeostasis regulation. This comprehensive review synthesizes cutting-edge research elucidating the multifaceted functions of spinal afferent neurons in maintaining metabolic equilibrium. Once predominantly associated with nociception and pathological states, these neurons are now recognized as integral components in the intricate network regulating feeding behavior, nutrient sensing, and energy balance. We explore the role of spinal afferents in food intake and how these neurons contribute to satiation signaling and meal termination through complex gut-brain axis pathways. The review also delves into the developing evidence that spinal afferents play a crucial role in energy expenditure regulation. We explore the ability of these neuronal fibers to carry signals that can modulate feeding behavior as well as adaptive thermogenesis in adipose tissue influencing basal metabolic rate, and thereby contributing to overall energy balance. This comprehensive analysis not only challenges existing paradigms but also opens new avenues for therapeutic interventions suggesting potential targets for treating metabolic disorders. In conclusion, this review highlights the need for a shift in our understanding of energy homeostasis, positioning spinal afferent neurons as key players in the intricate web of metabolic regulation.
Details
- Title: Subtitle
- Spinal afferent neurons: emerging regulators of energy balance and metabolism
- Creators
- Mohammad Jarrah - University of IowaDana Tasabehji - University of Iowa, Internal MedicineAviva Fraer - University of IowaMohamad Mokadem - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Frontiers in molecular neuroscience, Vol.17, 1479876
- DOI
- 10.3389/fnmol.2024.1479876
- PMID
- 39582948
- PMCID
- PMC11583444
- NLM abbreviation
- Front Mol Neurosci
- ISSN
- 1662-5099
- eISSN
- 1662-5099
- Publisher
- FRONTIERS MEDIA SA
- Grant note
- US Department of Veterans Affairs, VA Merit Review Program: I01 BX004774-05 Department Internal Medicine at University of Iowa Carver College of MedicineUniversity of Iowa Fraternal Order of Eagles Diabetes Research Center
The author(s) declare that financial support was received for the research, authorship, and/or publication of this article. MM is supported by funds from the US Department of Veterans Affairs, VA Merit Review Program (I01 BX004774-05), the Department Internal Medicine at University of Iowa Carver College of Medicine, and the University of Iowa Fraternal Order of Eagles Diabetes Research Center.
- Language
- English
- Date published
- 11/08/2024
- Academic Unit
- Gastroenterology and Hepatology; Internal Medicine
- Record Identifier
- 9984748160102771
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