Spinal cord lesions and clinical status in multiple sclerosis: A 1.5 T and 3 T MRI study

J.M. Stankiewicz; M. Neema; D.C. Alsop; B.C. Healy; A. Arora; G.J. Buckle; T. Chitnis; C.R.G. Guttmann; D. Hackney; R. Bakshi

doi:10.1016/j.jns.2008.11.009

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Spinal cord lesions and clinical status in multiple sclerosis: A 1.5 T and 3 T MRI study

Journal article

Peer reviewed

Spinal cord lesions and clinical status in multiple sclerosis: A 1.5 T and 3 T MRI study

J.M. Stankiewicz, M. Neema, D.C. Alsop, B.C. Healy, A. Arora, G.J. Buckle, T. Chitnis, C.R.G. Guttmann, D. Hackney and R. Bakshi

Journal of the neurological sciences, Vol.279(1), pp.99-105

04/15/2009

DOI: 10.1016/j.jns.2008.11.009

PMCID: PMC2679653

PMID: 19178916

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https://www.ncbi.nlm.nih.gov/pmc/articles/2679653View

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Abstract

Assess the relationship between spinal cord T2 hyperintense lesions and clinical status in multiple sclerosis (MS) with 1.5 and 3 T MRI. Whole cord T2-weighted fast spin-echo MRI was performed in 32 MS patients [Expanded Disability Status Scale (EDSS) score (mean ± SD: 2 ± 1.9), range 0–6.5]. Protocols at 1.5 T and 3 T were optimized and matched on voxel size. Moderate correlations were found between whole cord lesion volume and EDSS score at 1.5 T ( r s = .36, p = 0.04), but not at 3 T ( r s = 0.13, p = 0.46). Pyramidal Functional System Score (FSS) correlated with thoracic T2 lesion number ( r s = .46, p = 0.01) and total spinal cord lesion number ( r s = 0.37, p = 0.04) and volume ( r s = 0.37, p = 0.04) at 1.5 T. Bowel/bladder FSS correlated with T2 lesion volume and number in the cervical, thoracic, and total spine at 1.5 T ( r s 0.40–0.57, all p < 0.05). These MRI–FSS correlations were non-significant at 3 T. However, these correlation coefficients did not differ significantly between platforms (Choi's test p > 0.05). Correlations between whole cord lesion volume and timed 25-foot walk were non-significant at 1.5 T and 3 T ( p > 0.05). Lesion number and volume did not differ between MRI platforms in the MS group ( p > 0.05). Despite the use of higher field MRI strength, the link between spinal lesions and MS disability remains weak. The 1.5 T and 3 T protocols yielded similar results for many comparisons.

MRI

Multiple sclerosis

Spinal cord

Details

Title: Subtitle: Spinal cord lesions and clinical status in multiple sclerosis: A 1.5 T and 3 T MRI study
Creators: J.M. Stankiewicz - Brigham and Women's Hospital
M. Neema - Brigham and Women's Hospital
D.C. Alsop
B.C. Healy - Brigham and Women's Hospital
A. Arora - Brigham and Women's Hospital
G.J. Buckle - Brigham and Women's Hospital
T. Chitnis - Brigham and Women's Hospital
C.R.G. Guttmann - Brigham and Women's Hospital
D. Hackney
R. Bakshi - Brigham and Women's Hospital
Resource Type: Journal article
Publication Details: Journal of the neurological sciences, Vol.279(1), pp.99-105
DOI: 10.1016/j.jns.2008.11.009
PMID: 19178916
PMCID: PMC2679653
NLM abbreviation: J Neurol Sci
ISSN: 0022-510X
eISSN: 1878-5883
Publisher: Elsevier B.V
Language: English
Date published: 04/15/2009
Academic Unit: Psychiatry
Record Identifier: 9984627345202771

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