Journal article
Spinal dura mater: biophysical characteristics relevant to medical device development
Journal of medical engineering & technology, Vol.42(2), pp.128-139
02/2018
DOI: 10.1080/03091902.2018.1435745
PMCID: PMC7053539
PMID: 29569970
Abstract
Understanding the relevant biophysical properties of the spinal dura mater is essential to the design of medical devices that will directly interact with this membrane or influence the contents of the intradural space. We searched the literature and reviewed the pertinent characteristics for the design, construction, testing, and imaging of novel devices intended to perforate, integrate, adhere or reside within or outside of the spinal dura mater. The spinal dura mater is a thin tubular membrane composed of collagen and elastin fibres that varies in circumference along its length. Its mechanical properties have been well-described, with the longitudinal tensile strength exceeding the transverse strength. Data on the bioelectric, biomagnetic, optical and thermal characteristics of the spinal dura are limited and sometimes taken to be similar to those of water. While various modalities are available to visualise the spinal dura, magnetic resonance remains the best modality to segment its structure. The reaction of the spinal dura to imposition of a foreign body or other manipulations of it may compromise its biomechanical and immune-protective benefits. Therefore, dural sealants and replacements are of particular clinical, research and commercial interest. In conclusion, existing devices that are in clinical use for spinal cord stimulation, intrathecal access or intradural implantation largely adhere to traditional designs and their attendant limitations. However, if future devices are built with an understanding of the dura's properties incorporated more fully into the designs, there is potential for improved performance.
Details
- Title: Subtitle
- Spinal dura mater: biophysical characteristics relevant to medical device development
- Creators
- Sean J Nagel - a Center for Neurological Restoration , Cleveland Clinic , Cleveland , OH , USAChandan G Reddy - b Department of Neurosurgery , University of Iowa Hospitals and Clinics , Iowa City , IA , USALeonardo A Frizon - a Center for Neurological Restoration , Cleveland Clinic , Cleveland , OH , USAMatthieu K Chardon - c Department of Physiology , Northwestern University Feinberg School of Medicine , Chicago , IL , USAMarshall Holland - b Department of Neurosurgery , University of Iowa Hospitals and Clinics , Iowa City , IA , USAAndre G Machado - a Center for Neurological Restoration , Cleveland Clinic , Cleveland , OH , USAGeorge T Gillies - d Department of Mechanical and Aerospace Engineering , University of Virginia , Charlottesville , VA , USAMatthew A Howard III - b Department of Neurosurgery , University of Iowa Hospitals and Clinics , Iowa City , IA , USASaul Wilson - b Department of Neurosurgery , University of Iowa Hospitals and Clinics , Iowa City , IA , USA
- Resource Type
- Journal article
- Publication Details
- Journal of medical engineering & technology, Vol.42(2), pp.128-139
- DOI
- 10.1080/03091902.2018.1435745
- PMID
- 29569970
- PMCID
- PMC7053539
- NLM abbreviation
- J Med Eng Technol
- ISSN
- 0309-1902
- eISSN
- 1464-522X
- Publisher
- England
- Grant note
- TL1 TR001423 / NCATS NIH HHS
- Language
- English
- Date published
- 02/2018
- Academic Unit
- Neurology; Iowa Neuroscience Institute; Neurosurgery; Otolaryngology
- Record Identifier
- 9984020653902771
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