Spinal epidural granulocytic sarcoma in a child precedent to clinical manifestation of acute myeloid lymphoma: case report

Masaaki Takeda; Satoshi Yamaguchi; Kuniki Eguchi; Teruyuki Kajiume; Shinichiro Nishimura; Masao Kobayashi; Kaoru Kurisu

doi:10.2176/nmc.49.221

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Spinal epidural granulocytic sarcoma in a child precedent to clinical manifestation of acute myeloid lymphoma: case report

Journal article

Open access

Peer reviewed

Spinal epidural granulocytic sarcoma in a child precedent to clinical manifestation of acute myeloid lymphoma: case report

Masaaki Takeda, Satoshi Yamaguchi, Kuniki Eguchi, Teruyuki Kajiume, Shinichiro Nishimura, Masao Kobayashi and Kaoru Kurisu

Neurologia medico-chirurgica, Vol.49(5), pp.221-224

05/2009

DOI: 10.2176/nmc.49.221

PMID: 19465795

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Abstract

A 13-year-old boy presented with an epidural thoracic granulocytic sarcoma manifesting as rapidly progressive paraplegia preceding clinical manifestation of acute myeloid leukemia (AML). Magnetic resonance imaging revealed a thoracic epidural tumor. He underwent emergent laminectomy and the tumor was totally resected. The initial histological diagnosis was malignant lymphoma. The correct diagnosis of epidural granulocytic sarcoma and AML was established based on cell-surface markers and a chromosomal study of the bone marrow cells. A combination of chemotherapy and bone marrow transfusion achieved complete remission of leukemia. No evidence of AML has emerged over the 18-month follow-up period. Granulocytic sarcoma should be considered in the differential diagnosis of an epidural mass in pediatric patients with or without acute leukemia. Immediate diagnosis and appropriate treatment are recommended to prevent leukemic transformation.

Methylprednisolone - therapeutic use

Humans

Epidural Neoplasms - surgery

Exophthalmos - etiology

Male

Laminectomy

Spinal Neoplasms - drug therapy

Sarcoma, Myeloid - surgery

Thoracic Vertebrae - surgery

Bone Marrow Transplantation

Leukemia, Myeloid, Acute - drug therapy

Leukemia, Myeloid, Acute - surgery

Temporal Lobe - pathology

Orbit - pathology

Combined Modality Therapy

Paraplegia - etiology

Spinal Neoplasms - diagnosis

Remission Induction

Epidural Neoplasms - diagnosis

Magnetic Resonance Imaging

Leukemia, Myeloid, Acute - diagnosis

Antineoplastic Combined Chemotherapy Protocols - therapeutic use

Epidural Neoplasms - drug therapy

Adolescent

Spinal Neoplasms - surgery

Details

Title: Subtitle: Spinal epidural granulocytic sarcoma in a child precedent to clinical manifestation of acute myeloid lymphoma: case report
Creators: Masaaki Takeda - Department of Neurosurgery, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan. tkdmsk@hiroshima-u.ac.jp
Satoshi Yamaguchi
Kuniki Eguchi
Teruyuki Kajiume
Shinichiro Nishimura
Masao Kobayashi
Kaoru Kurisu
Resource Type: Journal article
Publication Details: Neurologia medico-chirurgica, Vol.49(5), pp.221-224
DOI: 10.2176/nmc.49.221
PMID: 19465795
NLM abbreviation: Neurol Med Chir (Tokyo)
ISSN: 0470-8105
eISSN: 1349-8029
Publisher: Japan
Language: English
Date published: 05/2009
Academic Unit: Neurosurgery
Record Identifier: 9984040208902771

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