Journal article
Spiradenocarcinoma Arising from a Spiradenocylindroma: Unusual Case with Lymphoepithelioma-Like Areas
Journal of cutaneous medicine and surgery, Vol.13(4), pp.215-220
07/2009
DOI: 10.2310/7750.2008.08059
PMID: 19706230
Abstract
Background: Hybrid skin adnexal tumors are common, and spiradenocylindroma is well described. Objective: However, malignant transformation in this setting is infrequent, especially resemblance to lymphoepithelioma-like carcinoma of skin, which is not associated with Epstein-Barr virus. Methods: A 65-year-old female presented with ataxia and a skin nodule composed of a hybrid adnexal tumor (spiradenoma and cylindroma) that transitioned into an undifferentiated carcinoma with attendant lymphocytes and plasma cells. There was widespread dissemination of the undifferentiated component to regional neck lymph nodes. Results: The undifferentiated component resembled a lymphoepithelioma-like carcinoma and showed focal evidence of tubular and squamous differentiation. The tumor was Epstein-Barr encoded RNAs (EBER) negative by in situ hybridization. No evidence of neuroendocrine differentiation was seen in the tumor, despite the patient having symptoms of paraneoplastic ataxia that improved after surgery. Conclusion: This case highlights the transition of a benign hybrid tumor (spiradenocylindroma) into a spiradenocarcinoma that resembled lymphoepithelioma-like carcinoma of skin. It also highlights two unusual features: widespread lymph node dissemination and presentation with paraneoplastic syndrome-associated ataxia.
Details
- Title: Subtitle
- Spiradenocarcinoma Arising from a Spiradenocylindroma: Unusual Case with Lymphoepithelioma-Like Areas
- Creators
- Runjan Chetty - From the Departments of Pathology, Otolaryngology/Head and Neck Surgery, and Radiation Oncology, University Health Network/University of Toronto, Toronto, ONBayardo Perez-Ordonez - From the Departments of Pathology, Otolaryngology/Head and Neck Surgery, and Radiation Oncology, University Health Network/University of Toronto, Toronto, ONRalph Gilbert - From the Departments of Pathology, Otolaryngology/Head and Neck Surgery, and Radiation Oncology, University Health Network/University of Toronto, Toronto, ONNitin A Pagedar - From the Departments of Pathology, Otolaryngology/Head and Neck Surgery, and Radiation Oncology, University Health Network/University of Toronto, Toronto, ONJohn Waldron - From the Departments of Pathology, Otolaryngology/Head and Neck Surgery, and Radiation Oncology, University Health Network/University of Toronto, Toronto, ONDanny Ghazarian - From the Departments of Pathology, Otolaryngology/Head and Neck Surgery, and Radiation Oncology, University Health Network/University of Toronto, Toronto, ON
- Resource Type
- Journal article
- Publication Details
- Journal of cutaneous medicine and surgery, Vol.13(4), pp.215-220
- DOI
- 10.2310/7750.2008.08059
- PMID
- 19706230
- ISSN
- 1203-4754
- eISSN
- 1615-7109
- Language
- English
- Date published
- 07/2009
- Academic Unit
- Otolaryngology
- Record Identifier
- 9984006421502771
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