Spiral Ganglion Neuron Projection Development to the Hindbrain in Mice Lacking Peripheral and/or Central Target Differentiation

Karen L Elliott; Jennifer Kersigo; Ning Pan; Israt Jahan; Bernd Fritzsch

doi:10.3389/fncir.2017.00025

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Spiral Ganglion Neuron Projection Development to the Hindbrain in Mice Lacking Peripheral and/or Central Target Differentiation

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Spiral Ganglion Neuron Projection Development to the Hindbrain in Mice Lacking Peripheral and/or Central Target Differentiation

Karen L Elliott, Jennifer Kersigo, Ning Pan, Israt Jahan and Bernd Fritzsch

Frontiers in neural circuits, Vol.11, pp.25-25

2017

DOI: 10.3389/fncir.2017.00025

PMCID: PMC5389974

PMID: 28450830

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Abstract

We investigate the importance of the degree of peripheral or central target differentiation for mouse auditory afferent navigation to the organ of Corti and auditory nuclei in three different mouse models: first, a mouse in which the differentiation of hair cells, but not central auditory nuclei neurons is compromised ( ); second, a mouse in which hair cell defects are combined with a delayed defect in central auditory nuclei neurons ( ), and third, a mouse in which both hair cells and central auditory nuclei are absent ( ). Our results show that neither differentiated peripheral nor the central target cells of inner ear afferents are needed (hair cells, cochlear nucleus neurons) for segregation of vestibular and cochlear afferents within the hindbrain and some degree of base to apex segregation of cochlear afferents. These data suggest that inner ear spiral ganglion neuron processes may predominantly rely on temporally and spatially distinct molecular cues in the region of the targets rather than interaction with differentiated target cells for a crude topological organization. These developmental data imply that auditory neuron navigation properties may have evolved before auditory nuclei.

Animals, Newborn

Basic Helix-Loop-Helix Transcription Factors - genetics

Cochlear Nucleus - embryology

Embryo, Mammalian

Nervous System Malformations - pathology

Spiral Ganglion - growth & development

Auditory Pathways - embryology

PAX2 Transcription Factor - genetics

Mice, Knockout

Cell Differentiation - genetics

Cochlear Nucleus - growth & development

Animals

Hair Cells, Auditory - physiology

Spiral Ganglion - pathology

beta-Galactosidase - metabolism

PAX2 Transcription Factor - deficiency

Spiral Ganglion - embryology

Mice

beta-Galactosidase - genetics

Cochlear Nucleus - cytology

Nervous System Malformations - genetics

Basic Helix-Loop-Helix Transcription Factors - deficiency

Rhombencephalon - pathology

Details

Title: Subtitle: Spiral Ganglion Neuron Projection Development to the Hindbrain in Mice Lacking Peripheral and/or Central Target Differentiation
Creators: Karen L Elliott - Department of Biology, University of IowaIowa City, IA, USA
Jennifer Kersigo - Department of Biology, University of IowaIowa City, IA, USA
Ning Pan - Department of Biology, University of IowaIowa City, IA, USA
Israt Jahan - Department of Biology, University of IowaIowa City, IA, USA
Bernd Fritzsch - Department of Biology, University of IowaIowa City, IA, USA
Resource Type: Journal article
Publication Details: Frontiers in neural circuits, Vol.11, pp.25-25
DOI: 10.3389/fncir.2017.00025
PMID: 28450830
PMCID: PMC5389974
NLM abbreviation: Front Neural Circuits
ISSN: 1662-5110
eISSN: 1662-5110
Publisher: Switzerland
Grant note: R03 DC013655 / NIDCD NIH HHS R01 DC005590 / NIDCD NIH HHS R03 DC015333 / NIDCD NIH HHS
Language: English
Date published: 2017
Academic Unit: Iowa Neuroscience Institute; Biology; Craniofacial Anomalies Research Center
Record Identifier: 9984070947702771

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