Journal article
Splenic marginal zone lymphoma: An indolent malignancy leading to the development of neurolymphomatosis
Muscle & nerve, Vol.55(3), pp.440-444
03/2017
DOI: 10.1002/mus.25404
PMID: 27625159
Abstract
Acute neuropathic pain and weakness with a sensory level in a patient with a history of lymphoma has a broad differential diagnosis. Evaluation of such a presentation often includes MRI, neurophysiologic studies, and cerebrospinal fluid evaluation. We report a patient with splenic marginal zone lymphoma who developed acute weakness, sensory loss, and neuropathic pain due to neurolymphomatosis.
Clinical evaluation, MRI of the lumbar spine, cerebrospinal fluid evaluation, electrodiagnostic (EDx) studies, and biopsy of a dorsal nerve root were undertaken.
EDx studies were consistent with an acute, acquired demyelinating sensorimotor polyradiculoneuropathy. Treatment with intravenous immunoglobulin and plasma exchange did not lead to clinical improvement. Ultimately, biopsy of a dorsal nerve root was performed and revealed neurolymphomatosis.
This case emphasizes that, when it can be performed safely, biopsy for suspected neurolymphomatosis is imperative for appropriate diagnosis and treatment. Muscle Nerve 55: 440-444, 2017.
Details
- Title: Subtitle
- Splenic marginal zone lymphoma: An indolent malignancy leading to the development of neurolymphomatosis
- Creators
- Christopher L Groth - University of VirginiaKathryn S Nevel - University of VirginiaKelly G Gwathmey - University of VirginiaFahad Bafakih - University of VirginiaDavid E Jones - University of Virginia
- Resource Type
- Journal article
- Publication Details
- Muscle & nerve, Vol.55(3), pp.440-444
- DOI
- 10.1002/mus.25404
- PMID
- 27625159
- ISSN
- 0148-639X
- eISSN
- 1097-4598
- Language
- English
- Date published
- 03/2017
- Academic Unit
- Neurology
- Record Identifier
- 9984303018302771
Metrics
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