Journal article
Split Outer Plexiform Layer Appearance (SOPLA) Represents an Acquired Cone Dysfunction Phenotype of Autoimmune Retinopathy
Retina (Philadelphia, Pa.), Vol.45(3), pp.522-531
03/2025
DOI: 10.1097/IAE.0000000000004332
PMID: 39964825
Abstract
Purpose:
Autoimmune retinopathy (AIR) is a poorly understood condition with a wide phenotypic spectrum and heterogeneous findings on clinical examination and imaging. In this study, we characterize the clinical features of a recently described phenotypic subtype of AIR with a distinct split outer plexiform layer appearance (SOPLA) on OCT.
Methods:
This was a retrospective, observational study of patients with a diagnosis of AIR seen at the University of Iowa between January 2007 and September 2023 who were found to have decreased visual acuity, central scotoma on visual field testing, SOPLA on OCT, and abnormal light-adapted electroretinogram, consistent with an acquired cone dysfunction. Clinical course and multimodal imaging and physiologic testing were reviewed.
Results:
Ten patients were identified in the retrospective cohort. All patients presented with bilateral, asymmetric, subacute, progressive central vision loss. A diagnosis of cancer was present or subsequently diagnosed in 5 out of 10 patients (50%). 40% of patients underwent treatment with immunosuppressives, and one patient underwent tumor resection, with partial visual recovery seen.
Conclusion:
Patients with SOPLA on OCT have an acquired cone dysfunction that is important to recognize, as treatment in some cases may result in improved or stabilized visual function.
Details
- Title: Subtitle
- Split Outer Plexiform Layer Appearance (SOPLA) Represents an Acquired Cone Dysfunction Phenotype of Autoimmune Retinopathy
- Creators
- Timothy M. Boyce - University of IowaChristopher Fortenbach - University of IowaMatthew Thurtell - University of IowaEdwin M. Stone - University of IowaIan C. Han - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Retina (Philadelphia, Pa.), Vol.45(3), pp.522-531
- Publisher
- LIPPINCOTT WILLIAMS & WILKINS
- DOI
- 10.1097/IAE.0000000000004332
- PMID
- 39964825
- ISSN
- 0275-004X
- eISSN
- 1539-2864
- Language
- English
- Electronic publication date
- 11/08/2024
- Date published
- 03/2025
- Academic Unit
- Neurology; The University of Iowa Institute for Vision Research; Iowa Neuroscience Institute; John and Marcia Carver Nonprofit Genetic Testing Laboratory; Ophthalmology and Visual Sciences
- Record Identifier
- 9984752659502771
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