Journal article
Spontaneous Hepatitis B Seroclearance upon Development of Hepatocellular Carcinoma
Case reports in gastroenterology, Vol.11(3), pp.797-802
12/21/2017
DOI: 10.1159/000484660
PMCID: PMC5875296
PMID: 29606938
Abstract
The spontaneous seroclearance of hepatitis B upon development of a hepatocellular carcinoma (HCC) is extremely rare. To date, there has been one published case series reporting hepatitis B seroconversion following HCC resection. We describe two novel cases of spontaneous hepatitis B seroclearance following the development of HCC, prior to resection. Following resection, specimens were HBsAg- and HBcAg-negative in both tumor and peritumor tissues. Although the precise mechanism of this is poorly understood, nonuniform integration of hepatitis B virus DNA within the liver could lead to selective tumorigenesis of HBsAg-producing cells, explaining the observed clearance of serum HBsAg with the development of HCC.
Details
- Title: Subtitle
- Spontaneous Hepatitis B Seroclearance upon Development of Hepatocellular Carcinoma
- Creators
- Sara Naimimohasses - St. James's HospitalOmar El Sherif - St. James's HospitalMohammad Ashfaq - St. James's HospitalNiamh Nolan - St. James's HospitalMasood Iqbal - St. James's HospitalSusan McKiernan - St. James's HospitalSuzanne Norris - St. James's Hospital
- Resource Type
- Journal article
- Publication Details
- Case reports in gastroenterology, Vol.11(3), pp.797-802
- DOI
- 10.1159/000484660
- PMID
- 29606938
- PMCID
- PMC5875296
- NLM abbreviation
- Case Rep Gastroenterol
- ISSN
- 1662-0631
- eISSN
- 1662-0631
- Publisher
- S. Karger AG
- Number of pages
- 6
- Language
- English
- Date published
- 12/21/2017
- Academic Unit
- Gastroenterology and Hepatology; Internal Medicine
- Record Identifier
- 9984772262202771
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