Spontaneous inhibitory synaptic currents mediated by a G protein-coupled receptor

Stephanie C Gantz; James R Bunzow; John T Williams

doi:10.1016/j.neuron.2013.04.013

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Spontaneous inhibitory synaptic currents mediated by a G protein-coupled receptor

Journal article

Open access

Peer reviewed

Spontaneous inhibitory synaptic currents mediated by a G protein-coupled receptor

Stephanie C Gantz, James R Bunzow and John T Williams

Neuron (Cambridge, Mass.), Vol.78(5), pp.807-812

06/05/2013

DOI: 10.1016/j.neuron.2013.04.013

PMCID: PMC3697754

PMID: 23764286

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https://doi.org/10.1016/j.neuron.2013.04.013View

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Abstract

G protein-coupled receptors (GPCRs) affect many physiological processes by modulating both intrinsic membrane conductances and synaptic transmission. This study describes spontaneous miniature inhibitory postsynaptic currents mediated by vesicular dopamine release acting locally on metabotropic D2 receptors leading to the activation of a G protein-coupled inwardly rectifying potassium conductance. Thus, individual exocytotic events result in spontaneous GPCR-mediated transmission, similar to synaptic activation of classical ligand-gated ion channels.

Mesencephalon - cytology

Receptors, G-Protein-Coupled - metabolism

Humans

Male

Inhibitory Postsynaptic Potentials - genetics

Dopamine Agents - pharmacology

Egtazic Acid - analogs & derivatives

Neurons - physiology

Organophosphorus Compounds - pharmacology

Female

Mice, Inbred DBA

Neurons - drug effects

Dopamine - metabolism

Levodopa - pharmacology

Colforsin - pharmacology

Mice, Inbred C57BL

Inhibitory Postsynaptic Potentials - physiology

Mice, Transgenic

Chelating Agents - pharmacology

Receptors, Dopamine D2 - genetics

GABA Antagonists - pharmacology

Tyrosine 3-Monooxygenase - genetics

Patch-Clamp Techniques

Animals

Egtazic Acid - pharmacology

Serotonin Agents - pharmacology

Analysis of Variance

Mice

In Vitro Techniques

Inhibitory Postsynaptic Potentials - drug effects

Details

Title: Subtitle: Spontaneous inhibitory synaptic currents mediated by a G protein-coupled receptor
Creators: Stephanie C Gantz - Vollum Institute, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA
James R Bunzow
John T Williams
Resource Type: Journal article
Publication Details: Neuron (Cambridge, Mass.), Vol.78(5), pp.807-812
Publisher: United States
DOI: 10.1016/j.neuron.2013.04.013
PMID: 23764286
PMCID: PMC3697754
ISSN: 0896-6273
eISSN: 1097-4199
Grant note: DA04523 / NIDA NIH HHS R01 DA004523 / NIDA NIH HHS
Language: English
Date published: 06/05/2013
Academic Unit: Molecular Physiology and Biophysics; Iowa Neuroscience Institute
Record Identifier: 9984065372802771

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