Journal article
Spontaneous regression of Langerhans cell histiocytosis: a case report
Surgical neurology, Vol.62(2), pp.136-140
2004
DOI: 10.1016/j.surneu.2003.10.003
PMID: 15261507
Abstract
Spontaneous regression of Langerhans cell histiocytosis (LCH) has been reported in skin, bone, and pulmonary lesions. However, such phenomena in the central nervous system (CNS) have not been described previously.
A case of LCH in the CNS with spontaneous regression is reported. A 2-year-old boy presented with general convulsion followed by frequent vomiting and diabetes insipidus. Magnetic resonance imaging (MRI) scan revealed numerous multifocal nodules predominantly in the left frontal lobe. The patient underwent surgery to remove part of the frontal lesion. Subsequent to surgery, residual lesions showed regression without any additional treatment, and clinical symptoms also subsided. The multiple lesions disappeared completely and did not relapse during 5-year observation.
Surgical resection and/or adjuvant therapy such as radiation and chemotherapy has been performed for the treatment of LCH in the CNS. However, there may be a subgroup of patients with multifocal brain LCH that regress spontaneously. Further clinical study is required to establish the natural course and prognostic factors of this disease.
Details
- Title: Subtitle
- Spontaneous regression of Langerhans cell histiocytosis: a case report
- Creators
- Satoshi Yamaguchi - Department of Neurosurgery, Hiroshima City Asa Hospital, Hiroshima City, Hiroshima, JapanShuichi Oki - Department of Neurosurgery, Hiroshima City Asa Hospital, Hiroshima City, Hiroshima, JapanKaoru Kurisu - Department of Neurosurgery, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
- Resource Type
- Journal article
- Publication Details
- Surgical neurology, Vol.62(2), pp.136-140
- DOI
- 10.1016/j.surneu.2003.10.003
- PMID
- 15261507
- NLM abbreviation
- Surg Neurol
- ISSN
- 0090-3019
- eISSN
- 1879-3339
- Publisher
- Elsevier Inc
- Language
- English
- Date published
- 2004
- Academic Unit
- Neurosurgery
- Record Identifier
- 9984040343002771
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