Stability of 3′-Deoxy-3′-[18F]Fluorothymidine Standardized Uptake Values in Head and Neck Cancer Over Time

Laura L Boles Ponto; Yusuf Menda; Kenneth Dornfeld; Timothy J Tewson; G. Leonard Watkins; John Sunderland; Michael M Graham; John Buatti

doi:10.1089/cbr.2009.0709

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Stability of 3′-Deoxy-3′-[18F]Fluorothymidine Standardized Uptake Values in Head and Neck Cancer Over Time

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Stability of 3′-Deoxy-3′-[18F]Fluorothymidine Standardized Uptake Values in Head and Neck Cancer Over Time

Laura L Boles Ponto, Yusuf Menda, Kenneth Dornfeld, Timothy J Tewson, G. Leonard Watkins, John Sunderland, Michael M Graham and John Buatti

Cancer biotherapy & radiopharmaceuticals, Vol.25(3), pp.361-363

06/2010

DOI: 10.1089/cbr.2009.0709

PMCID: PMC2936251

PMID: 20578842

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Abstract

The purpose of this study was to evaluate the consistency of 3′-deoxy-3′[ 18 F]fluorothymidine (FLT) standardized uptake values (SUVs) over the time course of imaging in head and neck cancer. Thirteen (13) subjects (all male; age: 56.9 ± 6.7 years) with squamous cell head and neck cancer, stage III/IV, were administered FLT and imaged dynamically for 1 hour over the tumor and then underwent whole-body (WB) imaging commencing at 74 ± 6 minutes. Imaging was repeated after 5 days of radiotherapy (10 Gy) and a single course of platinum-based chemotherapy. Volumes-of-interest (VOIs) were created on the last dynamic frame (SUV 60 ). The pretherapy WB and midtherapy images were coregistered to the dynamic sequence and VOIs were applied. Mean and maximum SUVs (SUV 60 and SUV WB ) and the change with treatment were evaluated. The correlations (Spearman's ρ ) between SUV 60 and SUV WB for all VOIs (pre- and midtherapy, n = 108 data pairs) were 0.98 for mean and 0.97 for maximum SUVs ( p < 0.0001). Average absolute differences between SUV 60 and SUV WB were 0.18 ± 0.15 and 0.29 ± 0.32 SUV units, respectively. Correlations (Spearman's ρ ) between the change in SUV with therapy were 0.90 for mean and 0.89 for maximum SUV ( p < 0.0001), with differences in the change values averaging 0.03 ± 0.36 and −0.17 ± 0.57 units, respectively. FLT SUVs are stable and comparable for images initiated between 55 and 100 minutes postinjection whether acquired pre- or midtherapy in head and neck cancer.

Short Communications

standardized uptake values

head and neck cancer

[18F]fluorothymidine

FLT

Details

Title: Subtitle: Stability of 3′-Deoxy-3′-[18F]Fluorothymidine Standardized Uptake Values in Head and Neck Cancer Over Time
Creators: Laura L Boles Ponto - Department of Radiology
Yusuf Menda - Department of Radiology
Kenneth Dornfeld - Department of Biochemistry
Timothy J Tewson - Department of Radiology
G. Leonard Watkins - Department of Radiology
John Sunderland - Department of Radiology
Michael M Graham - Department of Radiology
John Buatti - Department of Radiation Oncology
Resource Type: Journal article
Publication Details: Cancer biotherapy & radiopharmaceuticals, Vol.25(3), pp.361-363
DOI: 10.1089/cbr.2009.0709
PMID: 20578842
PMCID: PMC2936251
NLM abbreviation: Cancer Biother Radiopharm
ISSN: 1084-9785
eISSN: 1557-8852
Publisher: Mary Ann Liebert, Inc
Language: English
Date published: 06/2010
Academic Unit: Radiology; Pharmaceutical Sciences and Experimental Therapeutics; Physics and Astronomy; Radiation Oncology; Neurosurgery; Otolaryngology
Record Identifier: 9984046909902771

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