Stability of leukemia-associated immunophenotypes in precursor B-lymphoblastic leukemia/lymphoma : A single institution experience

Weina Chen; Nitin J KARANDIKAR; Robert W MCKENNA; Steven H KROFT

doi:10.1309/7R6MU7R9YWJBY5V4

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Stability of leukemia-associated immunophenotypes in precursor B-lymphoblastic leukemia/lymphoma : A single institution experience

Journal article

Open access

Peer reviewed

Stability of leukemia-associated immunophenotypes in precursor B-lymphoblastic leukemia/lymphoma : A single institution experience

Weina Chen, Nitin J KARANDIKAR, Robert W MCKENNA and Steven H KROFT

American journal of clinical pathology, Vol.127(1), pp.39-46

2007

DOI: 10.1309/7R6MU7R9YWJBY5V4

PMID: 17145625

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Abstract

Essentially all cases of precursor B-lymphoblastic leukemia/lymphoma (B-ALL) demonstrate multiple immunophenotypic aberrancies relative to normal maturing B-cell precursors (hematogones). The stability of these aberrancies has relevance to follow-up minimal residual disease analysis. We compared the immunophenotypes at diagnosis and relapse in 51 childhood and adult B-ALLs with flow cytometry (FC) using broad antibody panels. A total of 446 aberrancies were present at diagnosis (median, 9 per case; range, 2–14). All cases retained multiple aberrancies at relapse (median, 8 per case; range, 2–14). Antibody panels at relapse allowed assessment of 383 (85.9%) of the initial 446 aberrancies. Of these, 299 (78.1%) were persistent and 84 (21.9%) were lost at relapse. Overall, 73% of cases showed a loss of at least 1 aberrancy at relapse. However, new aberrancies were detected in 60% of cases. These findings suggest that FC is suitable for the detection of residual B-ALL, provided that follow-up studies are not too narrowly targeted.

Hematologic and hematopoietic diseases

Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis

Biological and medical sciences

Investigative techniques, diagnostic techniques (general aspects)

Medical sciences

Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques

Details

Title: Subtitle: Stability of leukemia-associated immunophenotypes in precursor B-lymphoblastic leukemia/lymphoma : A single institution experience
Creators: Weina Chen - University of Texas Southwestern Medical School, Dallas, United States
Nitin J KARANDIKAR - University of Texas Southwestern Medical School, Dallas, United States
Robert W MCKENNA - University of Texas Southwestern Medical School, Dallas, United States
Steven H KROFT - University of Texas Southwestern Medical School, Dallas, United States
Resource Type: Journal article
Publication Details: American journal of clinical pathology, Vol.127(1), pp.39-46
Publisher: American Society of Clinical Pathologists; Chicago, IL
DOI: 10.1309/7R6MU7R9YWJBY5V4
PMID: 17145625
ISSN: 0002-9173
eISSN: 1943-7722
Language: English
Date published: 2007
Academic Unit: Pathology
Record Identifier: 9984047607302771

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