Journal article
Stability of theophylline elimination rate
Clinical pharmacology and therapeutics, Vol.41(4), pp.388-391
04/1987
DOI: 10.1038/clpt.1987.46
PMID: 3549119
Abstract
The elimination rate for theophylline varies greatly among patients, but recommendations for maintenance dosing schedules have assumed relatively little intrapatient variability even over extended time periods. Reports of large intrapatient variability of theophylline elimination rate and consequent clearance raise concerns regarding this assumption and also challenge the practice of assuming relative constancy of elimination rate in the performance of bioavailability studies of slow‐release formulations. We therefore systematically studied under controlled conditions the elimination rate of theophylline in 10 patients over an extended time interval. The initial elimination rate constants ranged from 0.062 to 0.136 hours−1. The changes ranged from −5.9% to 9.4% of the initial value during intervals of 2 to 11 months. Correlation of the first and second values was 0.96. Thus the elimination rate of theophylline generally appears to vary little within individuals over time when studied under controlled conditions.
Clinical Pharmacology and Therapeutics (1987) 41, 388–391; doi:10.1038/clpt.1987.46
Details
- Title: Subtitle
- Stability of theophylline elimination rate
- Creators
- Gary Milavetz - University of IowaLeigh M Vaughan - University of IowaMiles M Weinberger - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Clinical pharmacology and therapeutics, Vol.41(4), pp.388-391
- DOI
- 10.1038/clpt.1987.46
- PMID
- 3549119
- ISSN
- 0009-9236
- eISSN
- 1532-6535
- Number of pages
- 4
- Grant note
- National Institutes of Allergy and Infectious Disease, National Institutes of Health (AI 16151) General Clinical Research Centers Program, Division of Research Resources (RR‐59)
- Language
- English
- Date published
- 04/1987
- Academic Unit
- Pharmacy; Stead Family Department of Pediatrics; Pharmacy Practice and Science
- Record Identifier
- 9984365900302771
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