Journal article
Staging of Head and Neck Squamous Cell Cancer with Extended-Field FDG-PET
Archives of otolaryngology--head & neck surgery, Vol.129(11), pp.1173-1178
11/01/2003
DOI: 10.1001/archotol.129.11.1173
PMID: 14623746
Abstract
Background Accurate baseline staging is necessary to appropriately treat head and neck squamous cell carcinoma. [F-18]-fluorodeoxyglucose positron emission tomography (FDG-PET) is valuable for locoregional staging of primary head and neck disease. The effectiveness of FDG-PET for the detection of distant metastatic or synchronous disease remains unproven.
Objective To investigate the utility of FDG-PET extended into the abdomen (extended-field FDG-PET) for wide-field staging of head and neck tumors.
Methods This is a prospective institutional study of 35 consecutive patients diagnosed with American Joint Committee on Cancer (AJCC)-defined stage II-IV squamous cell carcinoma of the oral cavity, oropharynx, or larynx between September 2000 and June 2002. Thirty-three patients (94%) were eligible for analysis. All patients were routinely staged with chest radiography, liver function tests, and extended-field FDG-PET. Chest or abdominal computed tomographic scans were used as corroborative studies and were obtained only when one of the above tests indicated distant disease.
Results Of 33 patients, 7 (21%) had evidence of distant disease by extend-field FDG-PET—4 with metastases and 3 with synchronous primary cancers of the aerodigestive tract. [F-18]-fluorodeoxyglucose PET detected hepatic, bone, gastrointestinal, and mediastinal disease not identified by chest radiography or liver function tests. Two of the 7 patients with FDG-avid distant disease had false-negative staging by all other tests, including computed tomography.
Conclusions Extended-field FDG-PET is feasible and may improve staging of primary head and neck squamous cell carcinoma. Use of staging FDG-PET must be explicitly described in reports from centers engaged in prospective research to facilitate comparison with historical results.
Details
- Title: Subtitle
- Staging of Head and Neck Squamous Cell Cancer with Extended-Field FDG-PET
- Creators
- David L. Schwartz - University of WashingtonJoseph Rajendran - University of WashingtonBevan Yueh - University of WashingtonMarc Coltrera - University of WashingtonYoshimi Anzai - University of WashingtonKenneth Krohn - University of WashingtonJanet Eary - University of Washington
- Resource Type
- Journal article
- Publication Details
- Archives of otolaryngology--head & neck surgery, Vol.129(11), pp.1173-1178
- DOI
- 10.1001/archotol.129.11.1173
- PMID
- 14623746
- NLM abbreviation
- Arch Otolaryngol Head Neck Surg
- ISSN
- 0886-4470
- eISSN
- 1538-361X
- Publisher
- American Medical Association
- Number of pages
- 6
- Grant note
- P01CA042045 / National Cancer Institute (http://data.elsevier.com/vocabulary/SciValFunders/100000054)
- Language
- English
- Date published
- 11/01/2003
- Academic Unit
- Otolaryngology
- Record Identifier
- 9984966853302771
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