Journal article
Staging tau pathology with tau PET in Alzheimer's disease: a longitudinal study
Translational psychiatry, Vol.11(1), pp.483-483
09/18/2021
DOI: 10.1038/s41398-021-01602-5
PMCID: PMC8449785
PMID: 34537810
Abstract
A biological research framework to define Alzheimer' disease with dichotomized biomarker measurement was proposed by National Institute on Aging-Alzheimer's Association (NIA-AA). However, it cannot characterize the hierarchy spreading pattern of tau pathology. To reflect in vivo tau progression using biomarker, we constructed a refined topographic
F-AV-1451 tau PET staging scheme with longitudinal clinical validation. Seven hundred and thirty-four participants with baseline
F-AV-1451 tau PET (baseline age 73.9 ± 7.7 years, 375 female) were stratified into five stages by a topographic PET staging scheme. Cognitive trajectories and clinical progression were compared across stages with or without further dichotomy of amyloid status, using linear mixed-effect models and Cox proportional hazard models. Significant cognitive decline was first observed in stage 1 when tau levels only increased in transentorhinal regions. Rates of cognitive decline and clinical progression accelerated from stage 2 to stage 3 and stage 4. Higher stages were also associated with greater CSF phosphorylated tau and total tau concentrations from stage 1. Abnormal tau accumulation did not appear with normal β-amyloid in neocortical regions but prompt cognitive decline by interacting with β-amyloid in temporal regions. Highly accumulated tau in temporal regions independently led to cognitive deterioration. Topographic PET staging scheme have potentials in early diagnosis, predicting disease progression, and studying disease mechanism. Characteristic tau spreading pattern in Alzheimer's disease could be illustrated with biomarker measurement under NIA-AA framework. Clinical-neuroimaging-neuropathological studies in other cohorts are needed to validate these findings.
Details
- Title: Subtitle
- Staging tau pathology with tau PET in Alzheimer's disease: a longitudinal study
- Creators
- Shi-Dong Chen - Shanghai Medical College of Fudan UniversityJia-Ying Lu - Fudan UniversityHong-Qi Li - Shanghai Medical College of Fudan UniversityYu-Xiang Yang - Shanghai Medical College of Fudan UniversityJie-Hui Jiang - Department of Shanghai Institute for Advanced Communication and Data Science, Shanghai University, Shanghai, ChinaMei Cui - Shanghai Medical College of Fudan UniversityChuan-Tao Zuo - Fudan UniversityLan Tan - Qingdao UniversityQiang Dong - Shanghai Medical College of Fudan UniversityJin-Tai Yu - Shanghai Medical College of Fudan UniversityAlzheimer’s Disease Neuroimaging Initiative
- Contributors
- Del D Miller (Contributor) - University of Iowa, Psychiatry
- Resource Type
- Journal article
- Publication Details
- Translational psychiatry, Vol.11(1), pp.483-483
- DOI
- 10.1038/s41398-021-01602-5
- PMID
- 34537810
- PMCID
- PMC8449785
- NLM abbreviation
- Transl Psychiatry
- ISSN
- 2158-3188
- eISSN
- 2158-3188
- Grant note
- UL1 TR001422 / NCATS NIH HHS P30 AG066512 / NIA NIH HHS CIHR U01 AG024904 / NIA NIH HHS
- Language
- English
- Date published
- 09/18/2021
- Academic Unit
- Psychiatry
- Record Identifier
- 9984280831302771
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