Journal article
Standards in Pupillography
Frontiers in neurology, Vol.10, pp.129-129
02/01/2019
DOI: 10.3389/fneur.2019.00129
PMCID: PMC6395400
PMID: 30853933
Abstract
The number of research groups studying the pupil is increasing, as is the number of publications. Consequently, new standards in pupillography are needed to formalize the methodology including recording conditions, stimulus characteristics, as well as suitable parameters of evaluation. Since the description of intrinsically photosensitive retinal ganglion cells (ipRGCs) there has been an increased interest and broader application of pupillography in ophthalmology as well as other fields including psychology and chronobiology. Color pupillography plays an important role not only in research but also in clinical observational and therapy studies like gene therapy of hereditary retinal degenerations and psychopathology. Stimuli can vary in size, brightness, duration, and wavelength. Stimulus paradigms determine whether rhodopsin-driven rod responses, opsin-driven cone responses, or melanopsin-driven ipRGC responses are primarily elicited. Background illumination, adaptation state, and instruction for the participants will furthermore influence the results. This standard recommends a minimum set of variables to be used for pupillography and specified in the publication methodologies. Initiated at the 32nd International Pupil Colloquium 2017 in Morges, Switzerland, the aim of this manuscript is to outline standards in pupillography based on current knowledge and experience of pupil experts in order to achieve greater comparability of pupillographic studies. Such standards will particularly facilitate the proper application of pupillography by researchers new to the field. First we describe general standards, followed by specific suggestions concerning the demands of different targets of pupil research: the afferent and efferent reflex arc, pharmacology, psychology, sleepiness-related research and animal studies.
Details
- Title: Subtitle
- Standards in Pupillography
- Creators
- Carina Kelbsch - Pupil Research Group, Centre for Ophthalmology, University Hospitals TübingenTorsten Strasser - Pupil Research Group, Centre for Ophthalmology, University Hospitals TübingenYanjun Chen - Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public HealthBeatrix Feigl - Institute of Health and Biomedical Innovation, Queensland University of TechnologyPaul D Gamlin - Department of Ophthalmology and Visual Sciences, University of Alabama at BirminghamRandy Kardon - Neuro-Ophthalmology Division, University of Iowa and Iowa City VA Healthcare SystemTobias Peters - Pupil Research Group, Centre for Ophthalmology, University Hospitals TübingenKathryn A Roecklein - Department of Psychology, University of PittsburghStuart R Steinhauer - VA Pittsburgh Healthcare System, VISN 4 MIRECC, University Drive CElemer Szabadi - Developmental Psychiatry, University of NottinghamAndrew J Zele - Institute of Health and Biomedical Innovation, Queensland University of TechnologyHelmut Wilhelm - Pupil Research Group, Centre for Ophthalmology, University Hospitals TübingenBarbara J Wilhelm - Pupil Research Group, Centre for Ophthalmology, University Hospitals Tübingen
- Resource Type
- Journal article
- Publication Details
- Frontiers in neurology, Vol.10, pp.129-129
- DOI
- 10.3389/fneur.2019.00129
- PMID
- 30853933
- PMCID
- PMC6395400
- NLM abbreviation
- Front Neurol
- ISSN
- 1664-2295
- eISSN
- 1664-2295
- Publisher
- Frontiers Media S.A
- Language
- English
- Date published
- 02/01/2019
- Academic Unit
- Iowa Neuroscience Institute; Ophthalmology and Visual Sciences
- Record Identifier
- 9984070979802771
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