Journal article
Staphylococcal and streptococcal superantigen exotoxins
Clinical microbiology reviews, Vol.26(3), pp.422-447
07/2013
DOI: 10.1128/cmr.00104-12
PMCID: PMC3719495
PMID: 23824366
Abstract
SUMMARY This review begins with a discussion of the large family of Staphylococcus aureus and beta-hemolytic streptococcal pyrogenic toxin T lymphocyte superantigens from structural and immunobiological perspectives. With this as background, the review then discusses the major known and possible human disease associations with superantigens, including associations with toxic shock syndromes, atopic dermatitis, pneumonia, infective endocarditis, and autoimmune sequelae to streptococcal illnesses. Finally, the review addresses current and possible novel strategies to prevent superantigen production and passive and active immunization strategies.
Details
- Title: Subtitle
- Staphylococcal and streptococcal superantigen exotoxins
- Creators
- Adam R Spaulding - Department of Microbiology, University of Iowa Carver College of Medicine, Iowa City, Iowa, USAWilmara Salgado-PabónPetra L KohlerAlexander R HorswillDonald Y M LeungPatrick M Schlievert
- Resource Type
- Journal article
- Publication Details
- Clinical microbiology reviews, Vol.26(3), pp.422-447
- Publisher
- United States
- DOI
- 10.1128/cmr.00104-12
- PMID
- 23824366
- PMCID
- PMC3719495
- ISSN
- 0893-8512
- eISSN
- 1098-6618
- Grant note
- R01 AI074283 / NIAID NIH HHS U54 AI57153 / NIAID NIH HHS U54 AI057153 / NIAID NIH HHS R01 AR41256 / NIAMS NIH HHS R01 AR041256 / NIAMS NIH HHS
- Language
- English
- Date published
- 07/2013
- Academic Unit
- Microbiology and Immunology; Internal Medicine
- Record Identifier
- 9984001218802771
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