Staphylococcal toxic shock syndrome erythroderma is associated with superantigenicity and hypersensitivity

Chandy C John; Micah Niermann; Bazak Sharon; Marnie L Peterson; David M Kranz; Patrick M Schlievert

doi:10.1086/648441

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Staphylococcal toxic shock syndrome erythroderma is associated with superantigenicity and hypersensitivity

Journal article

Open access

Peer reviewed

Staphylococcal toxic shock syndrome erythroderma is associated with superantigenicity and hypersensitivity

Chandy C John, Micah Niermann, Bazak Sharon, Marnie L Peterson, David M Kranz and Patrick M Schlievert

Clinical infectious diseases, Vol.49(12), pp.1893-1896

12/15/2009

DOI: 10.1086/648441

PMCID: PMC2787872

PMID: 19911998

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Abstract

Staphylococcal toxic shock syndrome (TSS) has rarely been reported without rash and desquamation. This study describes a patient who met all criteria for TSS except erythroderma and desquamation. The associated staphylococcal superantigen was enterotoxin B. We demonstrate that erythroderma depends on preexisting T cell hypersensitivity amplified by superantigenicity.

Staphylococcal Infections - diagnosis

Shock, Septic - etiology

Skin Tests

Enterotoxins - immunology

Dermatitis, Exfoliative - diagnosis

Humans

Adolescent

Female

Shock, Septic - diagnosis

Superantigens - immunology

Dermatitis, Exfoliative - etiology

Staphylococcal Infections - etiology

Details

Title: Subtitle: Staphylococcal toxic shock syndrome erythroderma is associated with superantigenicity and hypersensitivity
Creators: Chandy C John - Department of 1Pediatrics, University of Minnesota Medical School, Minneapolis, MN 55455, USA
Micah Niermann
Bazak Sharon
Marnie L Peterson
David M Kranz
Patrick M Schlievert
Resource Type: Journal article
Publication Details: Clinical infectious diseases, Vol.49(12), pp.1893-1896
Publisher: United States
DOI: 10.1086/648441
PMID: 19911998
PMCID: PMC2787872
ISSN: 1537-6591
eISSN: 1537-6591
Grant note: U54-AI57153 / NIAID NIH HHS R01 AI074283 / NIAID NIH HHS R01-AI064611 / NIAID NIH HHS U54 AI057153-065876 / NIAID NIH HHS R01 AI064611 / NIAID NIH HHS R01 AI064611-05 / NIAID NIH HHS R01 AI074283-21 / NIAID NIH HHS U54 AI057153 / NIAID NIH HHS
Language: English
Date published: 12/15/2009
Academic Unit: Microbiology and Immunology; Internal Medicine
Record Identifier: 9984001220702771

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