Journal article
Staphylococcus aureus Colonization before Infection Is Not Associated with Mortality among S. aureus―Infected Patients: A Meta-analysis
Infection control and hospital epidemiology, Vol.33(8), pp.796-802
2012
DOI: 10.1086/666628
PMID: 22759547
Abstract
Background and objective: The literature is conflicted as to whether people colonized with Staphylococcus aureus are at an increased risk of mortality. The aim of this meta-analysis was to review and analyze the current literature to determine whether prior history of S. aureus colonization is associated with mortality among S. aureus-infected patients.
Methods: The PUBMED databases were searched with keywords related to S. aureus colonization and mortality. After reviewing 380 article abstracts and 59 articles in detail, only 7 studies had data on the association between S. aureus colonization and mortality among S. aureus-infected patients. Crude estimates of study odds ratios (ORs) were calculated on the basis of data from subset analyses. We pooled crude ORs from the 7 studies using a random-effects model. Woolf's test for heterogeneity was assessed.
Results: When all studies were pooled in a random-effects model, no association between S. aureus colonization and mortality among S. aureus-infected patients was seen (pooled OR, 1.08 [95% confidence interval (CI), 0.32-3.66]; [Formula: see text]; heterogeneity [Formula: see text]). When the analyses were restricted to infection-attributable mortality, the association between colonization and mortality among S. aureus-infected patients was not statistically significant (pooled OR, 0.42 [95% CI, 0.15-1.21]; [Formula: see text]; heterogeneity [Formula: see text]).
Conclusions: S. aureus colonization was not associated with mortality among patients who developed an S. aureus infection. Interventions to decolonize S. aureus carriers may prevent S. aureus infections but may not be sufficient to prevent mortality.
Details
- Title: Subtitle
- Staphylococcus aureus Colonization before Infection Is Not Associated with Mortality among S. aureus―Infected Patients: A Meta-analysis
- Creators
- Marin L. S CHWEIZER - Department of Epidemiology, College of Public Health, University of Iowa, Iowa City, Iowa, United StatesAnn BOSSEN - College of Nursing, University of Iowa, Iowa City, Iowa, United StatesJennifer S MCDANEL - Department of Epidemiology, College of Public Health, University of Iowa, Iowa City, Iowa, United StatesLeslie K DENNIS - Department of Epidemiology, College of Public Health, University of Iowa, Iowa City, Iowa, United States
- Resource Type
- Journal article
- Publication Details
- Infection control and hospital epidemiology, Vol.33(8), pp.796-802
- Publisher
- University of Chicago Press
- DOI
- 10.1086/666628
- PMID
- 22759547
- ISSN
- 0899-823X
- eISSN
- 1559-6834
- Language
- English
- Date published
- 2012
- Academic Unit
- Epidemiology; Nursing
- Record Identifier
- 9984094569102771
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