Journal article
Startle Habituation and Midfrontal Theta Activity in Parkinson Disease
Journal of cognitive neuroscience, Vol.28(12), pp.1923-1932
12/01/2016
DOI: 10.1162/jocn_a_01012
PMCID: PMC6686857
PMID: 27417205
Abstract
The ability to adapt to aversive stimuli is critical for mental health. Here, we investigate the relationship between habituation to startling stimuli and startle-related activity in medial frontal cortex as measured by EEG in both healthy control participants and patients with Parkinson disease (PD). We report three findings. First, patients with PD exhibited normal initial startle responses but reduced startle habituation relative to demographically matched controls. Second, control participants had midfrontal EEG theta activity in response to startling stimuli, and this activity was attenuated in patients with PD. Finally, startle-related midfrontal theta activity was correlated with the rate of startle habituation. These data indicate that impaired startle habituation in PD is a result of attenuated midfrontal cognitive control signals. Our findings could provide insight into the frontal regulation of startle habituation.
Details
- Title: Subtitle
- Startle Habituation and Midfrontal Theta Activity in Parkinson Disease
- Creators
- Kuan-Hua Chen - 2University of New MexicoKatrina L Okerstrom - 2University of New MexicoJonathan R Kingyon - 2University of New MexicoSteven W Anderson - 2University of New MexicoJames F Cavanagh - 2University of New MexicoNandakumar S Narayanan - 2University of New Mexico
- Resource Type
- Journal article
- Publication Details
- Journal of cognitive neuroscience, Vol.28(12), pp.1923-1932
- DOI
- 10.1162/jocn_a_01012
- PMID
- 27417205
- PMCID
- PMC6686857
- NLM abbreviation
- J Cogn Neurosci
- ISSN
- 0898-929X
- eISSN
- 1530-8898
- Publisher
- MIT Press
- Language
- English
- Date published
- 12/01/2016
- Academic Unit
- Neurology; Iowa Neuroscience Institute
- Record Identifier
- 9984014020802771
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