State dependent gene–environment interaction: Serotonin transporter gene–child abuse interaction associated with suicide attempt history among depressed psychiatric inpatients

Gen Shinozaki; Magdalena Romanowicz; Victoria Passov; James Rundell; David Mrazek; Simon Kung

doi:10.1016/j.jad.2012.11.043

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State dependent gene–environment interaction: Serotonin transporter gene–child abuse interaction associated with suicide attempt history among depressed psychiatric inpatients

Journal article

Peer reviewed

State dependent gene–environment interaction: Serotonin transporter gene–child abuse interaction associated with suicide attempt history among depressed psychiatric inpatients

Gen Shinozaki, Magdalena Romanowicz, Victoria Passov, James Rundell, David Mrazek and Simon Kung

Journal of affective disorders, Vol.147(1-3), pp.373-378

05/2013

DOI: 10.1016/j.jad.2012.11.043

PMID: 23261136

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Abstract

The serotonin transporter gene polymorphism (5HTTLPR) and child abuse history have been associated with an increased suicide risk for general population, but such association is not clear among psychiatric depressed inpatients. A chart review identified 422 depressed inpatients genotyped for 5HTTLPR. Child abuse and suicide attempt history were recorded. The relationship between 5HTTLPR, child abuse, and suicide attempts were analyzed. There was a significant relationship between 5HTTLPR and history of suicide attempt (the long/long versus the short carriers, 47.9% versus 31.8%, p=0.0015). There was also a significant main effect from child abuse history (abused versus not abused, 45.1% versus 28.6%, p=0.0001). The likelihood ratio test showed a significant result for the l/l genotype group with child abuse history (odds ratio 4.11, χ2 = 23.5, p<0.0001). No significant result was obtained from other groups. This is a retrospective study based on chart review. Replication with more standardized research setting for measurements of child abuse history and suicide attempt history is needed. The rs25531 variant among a long allele (long-A and long-G) of 5HTTLPR was not genotyped. In addition to the direct effect from 5HTTLPR and child abuse history, an interaction between the 5HTTLPR gene and child abuse history influenced psychiatric profiles of depressed inpatients. Contrary to the widely recognized “reactivity” associated with the short allele, our patients with the l/l genotype and child abuse history showed significantly severer psychiatric pathology than short carriers with child abuse history.

Depression

Child abuse

Serotonin transporter gene

Gene–environment interaction

5HTTLPR

Suicide attempt

Details

Title: Subtitle: State dependent gene–environment interaction: Serotonin transporter gene–child abuse interaction associated with suicide attempt history among depressed psychiatric inpatients
Creators: Gen Shinozaki - Department of Psychiatry, University of South Dakota, United States
Magdalena Romanowicz - Department of Psychiatry and Behavioral Sciences Stanford University, Stanford, CA, United States
Victoria Passov - Aurora Medical Center, Oshosh, WI, United States
James Rundell - Tamber, Plymouth, MN, United States
David Mrazek - Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN, United States
Simon Kung - Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN, United States
Resource Type: Journal article
Publication Details: Journal of affective disorders, Vol.147(1-3), pp.373-378
DOI: 10.1016/j.jad.2012.11.043
PMID: 23261136
NLM abbreviation: J Affect Disord
ISSN: 0165-0327
eISSN: 1573-2517
Publisher: Elsevier B.V
Language: English
Date published: 05/2013
Academic Unit: Psychiatry; Anesthesia; Neurosurgery
Record Identifier: 9984003962202771

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