Journal article
Statin Therapy in Patients With Chronic Kidney Disease Undergoing Percutaneous Coronary Intervention (from the Evaluation of Drug Eluting Stents and Ischemic Events Registry)
The American journal of cardiology, Vol.113(4), pp.621-625
02/15/2014
DOI: 10.1016/j.amjcard.2013.11.006
PMID: 24342762
Abstract
Secondary prevention trials have demonstrated the efficacy of statins in reducing cardiovascular morbidity and mortality in patients with coronary artery disease and events after percutaneous coronary intervention (PCI). However, there are few data describing the clinical value of statins in patients with coronary artery disease and chronic kidney disease (CKD) undergoing PCI. Of 10,148 patients who entered into Evaluation of Drug Eluting Stents and Ischemic Events, a multicenter registry of unselected patients undergoing PCI from July 2004 to December 2007, we studied 2,306 patients with CKD (estimated glomerular filtration rate <= 60 ml/min based on the Modified Diet in Renal Disease calculation). Patients were stratified into those receiving statins at discharge (n = 1,833, 79%) or not (n = 473, 21%). Patients in the statin group had a greater prevalence of hypertension, recent myocardial infarction (MI), and use of 13 blockers and angiotensin-converting enzyme inhibitors. Outcomes were assessed from discharge through 1-year follow-up. One-year all-cause mortality was 5.7% in statin group versus 8.7% in the no statin group (adjusted hazard ratio 0.55, 95% confidence interval 0.34 to 0.88). The composite of death, MI, and repeat revascularization was lower in statin group (adjusted hazard ratio 0.71, 95% confidence interval 0.51 to 0.99). In conclusion, among patients with CKD undergoing PCI, the prescription of statins at hospital discharge was associated with a significant improvement in subsequent outcomes including mortality and composite end point of death, MI, and repeat revascularization. (C) 2014 Elsevier Inc. All rights reserved.
Details
- Title: Subtitle
- Statin Therapy in Patients With Chronic Kidney Disease Undergoing Percutaneous Coronary Intervention (from the Evaluation of Drug Eluting Stents and Ischemic Events Registry)
- Creators
- Tarun W. Dasari - University of Oklahoma Health Sciences CenterDavid J. Cohen - St. Luke's HospitalNeal S. Kleiman - Houston MethodistMichelle J. Keyes - Baim Institute for Clinical ResearchChen-Hsing Yen - Baim Institute for Clinical ResearchElias B. Hanna - University of Oklahoma Health Sciences CenterJorge F. Saucedo - NorthShore University HealthSystem
- Resource Type
- Journal article
- Publication Details
- The American journal of cardiology, Vol.113(4), pp.621-625
- DOI
- 10.1016/j.amjcard.2013.11.006
- PMID
- 24342762
- NLM abbreviation
- Am J Cardiol
- ISSN
- 0002-9149
- eISSN
- 1879-1913
- Publisher
- Elsevier
- Number of pages
- 5
- Language
- English
- Date published
- 02/15/2014
- Academic Unit
- Cardiovascular Medicine; Internal Medicine
- Record Identifier
- 9984359840302771
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