Statin Therapy is Associated with Decreased Pulmonary Vascular Pressures in Severe COPD

Robert M Reed; Aldo Iacono; Andrew DeFilippis; Steven Jones; Michael Eberlein; Noah Lechtzin; Reda E Girgis

doi:10.3109/15412555.2011.558545

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Statin Therapy is Associated with Decreased Pulmonary Vascular Pressures in Severe COPD

Journal article

Open access

Statin Therapy is Associated with Decreased Pulmonary Vascular Pressures in Severe COPD

Robert M Reed, Aldo Iacono, Andrew DeFilippis, Steven Jones, Michael Eberlein, Noah Lechtzin and Reda E Girgis

Chronic obstructive pulmonary disease, Vol.8(2), pp.96-102

04/20/2011

DOI: 10.3109/15412555.2011.558545

PMID: 21495837

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Abstract

Background: Pulmonary hypertension (PH) in COPD carries a poor prognosis. Statin therapy has been associated with numerous beneficial clinical effects in COPD, including a possible improvement in PH. We examined the association between statin use and pulmonary hemodynamics in a well-characterized cohort of patients undergoing evaluation for lung transplantation. Methods: We conducted a cross-sectional analysis of 112 subjects evaluated for lung transplant with a diagnosis of COPD. Clinical characteristics, pulmonary function, cardiac catheterization findings and medical comorbidities were compared between statins users and non-users. Results: Thirty-four (30%) subjects were receiving statin therapy. Statin users were older and had an increased prevalence of systemic hypertension and coronary artery disease (CAD). Mean pulmonary arterial pressure (mPAP) in the statin group was lower [26 ± 7 vs 29 ± 7 mmHg, p = 0.02], as was pulmonary artery wedge pressure (PAWP) [12 ± 5 vs. 15 ± 6 mmHg, p = 0.02]. Pulmonary vascular resistance did not differ between the groups. In multiple regression analysis, statin use was associated with a 4.2 mmHg (95% CI: 2 to 6.4, p = <0.001) lower PAWP and a 2.6 mmHg (95% CI: 0.3 to 4.9, p = 0.03) reduction in mPAP independent of PAWP. Conclusions: In patients with severe COPD, statin use is associated with significantly lower PAWP and mPAP. These finding should be evaluated prospectively.

Details

Title: Subtitle: Statin Therapy is Associated with Decreased Pulmonary Vascular Pressures in Severe COPD
Creators: Robert M Reed - University of Maryland School of Medicine, Division of Pulmonary and Critical Care Medicine, Baltimore, Maryland, USA,1
Aldo Iacono - University of Maryland School of Medicine, Division of Pulmonary and Critical Care Medicine, Baltimore, Maryland, USA,1
Andrew DeFilippis - Johns Hopkins University School of Medicine, Division of Cardiology, Baltimore, Maryland, USA3
Steven Jones - Johns Hopkins University School of Medicine, Division of Cardiology, Baltimore, Maryland, USA3
Michael Eberlein - Johns Hopkins University School of Medicine, Division of Pulmonary and Critical Care Medicine, Baltimore, Maryland, USA,2
Noah Lechtzin - Johns Hopkins University School of Medicine, Division of Pulmonary and Critical Care Medicine, Baltimore, Maryland, USA,2
Reda E Girgis - Johns Hopkins University School of Medicine, Division of Pulmonary and Critical Care Medicine, Baltimore, Maryland, USA,2
Resource Type: Journal article
Publication Details: Chronic obstructive pulmonary disease, Vol.8(2), pp.96-102
DOI: 10.3109/15412555.2011.558545
PMID: 21495837
NLM abbreviation: COPD
ISSN: 1541-2555
eISSN: 1541-2563
Publisher: Informa Healthcare
Language: English
Date published: 04/20/2011
Academic Unit: Pulmonary, Critical Care, and Occupational Medicine; Internal Medicine
Record Identifier: 9984094673902771

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