Journal article
Statin Use for the Primary Prevention of Cardiovascular Disease in Adults US Preventive Services Task Force Recommendation Statement
JAMA : the journal of the American Medical Association, Vol.316(19), pp.1997-2007
11/15/2016
DOI: 10.1001/jama.2016.15450
PMID: 27838723
Abstract
IMPORTANCE Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in the United States, accounting for 1 of every 3 deaths among adults.
OBJECTIVE To update the 2008 US Preventive Services Task Force (USPSTF) recommendation on screening for lipid disorders in adults.
EVIDENCE REVIEW The USPSTF reviewed the evidence on the benefits and harms of screening for and treatment of dyslipidemia in adults 21 years and older; the benefits and harms of statin use in reducing CVD events and mortality in adults without a history of CVD events; whether the benefits of statin use vary by subgroup, clinical characteristics, or dosage; and the benefits of various treatment strategies in adults 40 years and older without a history of CVD events.
CONCLUSIONS AND RECOMMENDATIONS The USPSTF recommends initiating use of low-to moderate-dose statins in adults aged 40 to 75 years without a history of CVD who have 1 or more CVD risk factors (dyslipidemia, diabetes, hypertension, or smoking) and a calculated 10-year CVD event risk of 10% or greater (B recommendation). The USPSTF recommends that clinicians selectively offer low-to moderate-dose statins to adults aged 40 to 75 years without a history of CVD who have 1 or more CVD risk factors and a calculated 10-year CVD event risk of 7.5% to 10% (C recommendation). The USPSTF concludes that the current evidence is insufficient to assess the balance of benefits and harms of initiating statin use in adults 76 years and older (I statement).
Details
- Title: Subtitle
- Statin Use for the Primary Prevention of Cardiovascular Disease in Adults US Preventive Services Task Force Recommendation Statement
- Creators
- Kirsten Bibbins-Domingo - University of California, San FranciscoDavid C. Grossman - Kaiser Permanente Washington Health Research InstituteSusan J. Curry - University of IowaKarinaW Davidson - Columbia UniversityJohn W. Epling - SUNY Upstate Medical UniversityFrancisco A. R. Garcia - Pima Cty Dept Hlth, Tucson, AZ USAMatthew W. Gillman - Harvard Pilgrim Health CareAlex R. Kemper - Duke UniversityAlex H. Krist - Virginia Commonwealth UniversityAnn E. Kurth - Yale UniversityC. Seth Landefeld - University of Alabama at BirminghamMichael L. LeFevre - University of MissouriCarol M. Mangione - University of California, Los AngelesWilliam R. Phillips - University of WashingtonDouglas K. Owens - Stanford UniversityMaureen G. Phipps - Brown UniversityMichael P. Pignone - The University of Texas at AustinUS Preventive Services Task Force
- Resource Type
- Journal article
- Publication Details
- JAMA : the journal of the American Medical Association, Vol.316(19), pp.1997-2007
- DOI
- 10.1001/jama.2016.15450
- PMID
- 27838723
- NLM abbreviation
- JAMA
- ISSN
- 0098-7484
- eISSN
- 1538-3598
- Publisher
- Amer Medical Assoc
- Number of pages
- 11
- Grant note
- USPSTF
- Language
- English
- Date published
- 11/15/2016
- Academic Unit
- Health Management and Policy; Community and Behavioral Health
- Record Identifier
- 9984366291702771
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