Journal article
Statin administration improves vascular function in heart failure with preserved ejection fraction
Journal of applied physiology (1985), Vol.136(4), pp.877-888
04/01/2024
DOI: 10.1152/japplphysiol.00775.2023
PMCID: PMC11286274
PMID: 38385181
Abstract
Heart failure with preserved ejection fraction (HFpEF) is characterized by impaired vascular endothelial function that may be improved by hydroxy-methylglutaryl-CoA (HMG-CoA) reductase enzyme inhibition. Thus, using a parallel, double-blind, placebo-controlled design, this study evaluated the efficacy of 30-day atorvastatin administration (10 mg daily) on peripheral vascular function and biomarkers of inflammation and oxidative stress in 16 patients with HFpEF [Statin: n = 8, 74 +/- 6 yr, ejection fraction (EF) 52-73%; Placebo: n = 8, 67 +/- 9 yr, EF 56-72%]. Flow-mediated dilation (FMD) and sustained-stimulus FMD (SS-FMD) during handgrip (HG) exercise, reactive hyperemia (RH), and blood flow during HG exercise were evaluated to assess conduit vessel function, microvascular function, and exercising muscle blood flow, respectively. FMD improved following statin administration (pre, 3.33 +/- 2.13%; post, 5.23 +/- 1.35%; P < 0.01), but was unchanged in the placebo group. Likewise, SS-FMD, quantified using the slope of changes in brachial artery diameter in response to increases in shear rate, improved following statin administration (pre: 5.31e(-5) +/- 3.85e(-5) mm/s(-1); post: 8.54e(-5) +/- 4.98e(-5) mm/s(-1); P = 0.03), with no change in the placebo group. Reactive hyperemia and exercise hyperemia responses were unchanged in both statin and placebo groups. Statin administration decreased markers of lipid peroxidation (malondialdehyde, MDA) (pre, 0.652 +/- 0.095; post, 0.501 +/- 0.094; P = 0.04), whereas other inflammatory and oxidative stress biomarkers were unchanged. Together, these data provide new evidence for the efficacy of low-dose statin administration to improve brachial artery endothelium-dependent vasodilation, but not microvascular function or exercising limb blood flow, in patients with HFpEF, which may be due in part to reductions in oxidative stress.
Details
- Title: Subtitle
- Statin administration improves vascular function in heart failure with preserved ejection fraction
- Creators
- Jarred J. Iacovelli - University of UtahJeremy K. Alpenglow - University of UtahStephen M. Ratchford - Geriatric Research Education and Clinical CenterJesse C. Craig - Geriatric Research Education and Clinical CenterJonah M. Simmons - University of UtahJia Zhao - University of UtahVan Reese - University of UtahKanokwan Bunsawat - University of UtahChristy L. Ma - University of UtahJohn J. Ryan - University of UtahD. Walter Wray - University of Utah
- Resource Type
- Journal article
- Publication Details
- Journal of applied physiology (1985), Vol.136(4), pp.877-888
- DOI
- 10.1152/japplphysiol.00775.2023
- PMID
- 38385181
- PMCID
- PMC11286274
- NLM abbreviation
- J Appl Physiol (1985)
- ISSN
- 8750-7587
- eISSN
- 1522-1601
- Publisher
- Amer Physiological Soc
- Number of pages
- 12
- Grant note
- CX002152; IK2RX003670 / U.S. Department of Veterans Affairs Grants; US Department of Veterans Affairs HL162856; HL139451 / NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA
- Language
- English
- Date published
- 04/01/2024
- Academic Unit
- Health, Sport, and Human Physiology
- Record Identifier
- 9984948042802771
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