Journal article
Statin and Metformin Use Prolongs Survival in Patients With Resectable Pancreatic Cancer
Pancreas, Vol.45(1), pp.64-70
01/01/2016
DOI: 10.1097/MPA.0000000000000470
PMID: 26474429
Abstract
Objectives The aim of this study was to investigate the impact of statin and metformin therapy on disease outcome for patients with pancreatic ductal adenocarcinoma (PDAC).
Methods This retrospective study included 171 PDAC patients who underwent surgical resection at the Stanford Cancer Institute between 1998 and 2013. No patients received neoadjuvant therapy. Statin and metformin use was defined as use during initial consult and continuing upon discharge from the hospital after surgery. Dose of each medication was recorded, as was the type of statin taken.
Results The median follow-up for all patients was 11.23 months (range, 0.2-105.0 months). Among the 171 patients included in our analysis, 18 patients (10.5%) took metformin and 34 patients (19.9%) took statins. Statin use was associated with better overall survival (OS) in patients with PDAC (P = 0.011). Metformin use was also associated with better OS (P = 0.035). The use of statins remained significant on multivariate analysis for OS (P = 0.014; hazards ratio, 0.33; 95% confidence interval, 0.139-0.799), but metformin use did not (P = 0.33; hazards ratio 0.60, 95% confidence interval, 0.211-1.675).
Conclusions Statin and metformin use is associated with improved OS in patients with resectable PDAC. These medications should be further investigated for possible long-term use in the general population.
Details
- Title: Subtitle
- Statin and Metformin Use Prolongs Survival in Patients With Resectable Pancreatic Cancer
- Creators
- Margaret M. Kozak - Stanford UniversityEric M. Anderson - Stanford UniversityRie von Eyben - Stanford UniversityJonathan S. Pai - Stanford UniversityGeorge A. Poultsides - Stanford UniversityBrendan C. Visser - Stanford UniversityJeffrey A. Norton - Stanford UniversityAlbert C. Koong - Stanford UniversityDaniel T. Chang - Stanford University
- Resource Type
- Journal article
- Publication Details
- Pancreas, Vol.45(1), pp.64-70
- Publisher
- Lippincott Williams & Wilkins
- DOI
- 10.1097/MPA.0000000000000470
- PMID
- 26474429
- ISSN
- 0885-3177
- eISSN
- 1536-4828
- Number of pages
- 7
- Language
- English
- Date published
- 01/01/2016
- Academic Unit
- Radiation Oncology
- Record Identifier
- 9984313093802771
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