Statin-induced necrotizing autoimmune myopathy: An uncommon complication of a commonly used medication

Yehia Saleh; Khader Herzallah; Mohamed Hassanein; Howard T. Chang

doi:10.1016/j.jsha.2019.08.001

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Statin-induced necrotizing autoimmune myopathy: An uncommon complication of a commonly used medication

Journal article

Open access

Peer reviewed

Statin-induced necrotizing autoimmune myopathy: An uncommon complication of a commonly used medication

Yehia Saleh, Khader Herzallah, Mohamed Hassanein and Howard T. Chang

Journal Of The Saudi Heart Association, Vol.31(4), pp.269-272

10/01/2019

DOI: 10.1016/j.jsha.2019.08.001

PMCID: PMC6727174

PMID: 31516306

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Abstract

A well-known side effect of statin therapy is myopathy. We report a case of statin induced necrotizing autoimmune myopathy, a rare variant of statin-induced myopathy. A 64-year-old gentleman on atorvastatin presented with muscle weakness. Initial laboratory results showed elevated liver function tests, a creatine phosphokinase (CPK) of 8200 IU/L, and positive urine myoglobin. Despite discontinuing atorvastatin, his CPK remained persistently elevated. Muscle biopsy was consistent with necrotizing myopathy. Anti-HMG CoA reductase antibody was strongly positive. Steroids followed by intravenous immunoglobulin were given. The patient's muscle weakness, CPK, and liver functions gradually improved, and he was eventually discharged on oral steroids. Statin induced necrotizing autoimmune myopathy should be considered when discontinuing statin does not lead to muscle recovery and improvement in CPK. Diagnosis is confirmed by positive anti-HMG-CoA reductase autoantibody. (C) 2019 The Authors. Production and hosting by Elsevier B.V. on behalf of King Saud University.

Cardiac & Cardiovascular Systems

Cardiovascular System & Cardiology

Life Sciences & Biomedicine

Science & Technology

Details

Title: Subtitle: Statin-induced necrotizing autoimmune myopathy: An uncommon complication of a commonly used medication
Creators: Yehia Saleh - Michigan State University
Khader Herzallah - Michigan State University
Mohamed Hassanein - Michigan State University
Howard T. Chang - Sparrow Health System
Resource Type: Journal article
Publication Details: Journal Of The Saudi Heart Association, Vol.31(4), pp.269-272
DOI: 10.1016/j.jsha.2019.08.001
PMID: 31516306
PMCID: PMC6727174
NLM abbreviation: J Saudi Heart Assoc
ISSN: 1016-7315
eISSN: 2212-5043
Publisher: Elsevier
Number of pages: 4
Language: English
Date published: 10/01/2019
Academic Unit: Internal Medicine
Record Identifier: 9984755392502771

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