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Statin therapy improves locomotor muscle microvascular reactivity in patients with heart failure with preserved ejection fraction
Journal article   Peer reviewed

Statin therapy improves locomotor muscle microvascular reactivity in patients with heart failure with preserved ejection fraction

Jarred J. Iacovelli, Jeremy K. Alpenglow, Stephen M. Ratchford, Jesse C. Craig, Jonah M. Simmons, Jia Zhao, Van Reese, Kanokwan Bunsawat, Christy L. Ma, John J. Ryan, …
American journal of physiology. Heart and circulatory physiology, Vol.327(4), pp.H859-H865
10/01/2024
DOI: 10.1152/ajpheart.00427.2024
PMCID: PMC11482264
PMID: 39120468
url
https://pmc.ncbi.nlm.nih.gov/articles/PMC11482264/View
Open Access

Abstract

Peripheral microvascular dysfunction has been documented in patients with heart failure with preserved ejection fraction (HFpEF), which may be related to elevated levels of inflammation and oxidative stress. Unfortunately, few strategies have been identified to effectively ameliorate this disease-related derangement. Thus, using a parallel, double-blind, placebo-controlled design, this study evaluated the efficacy of 30-day atorvastatin administration (10 mg daily) on lower limb microvascular reactivity, functional capacity, and biomarkers of inflammation and oxidative stress in patients with HFpEF (statin, n = 8, 76 +/- 6 yr; placebo, n = 8, 68 +/- 9 yr). The passive limb movement (PLM)-induced hyperemic response and 6-min walk test (6MWT) distance were evaluated to assess ambulatory muscle microvascular function and functional capacity, respectively. Circulating biomarkers were also measured to assess the contribution of changes in inflammation and redox balance to these outcomes. The total hyperemic response to PLM, assessed as leg blood flow area under the curve (LBFAUC), increased following the statin intervention (pre, 60 +/- 68 mL; post, 164 +/- 90 mL; P < 0.01), whereas these variables were unchanged in the placebo group (P = 0.99). There were no significant differences in 6MWT distance following statin or placebo intervention. Malondialdehyde (MDA), a marker of lipid peroxidation, was significantly reduced following the statin intervention (pre, 0.68 +/- 0.10; post, 0.51 +/- 0.11; P < 0.01) while other circulating biomarkers were unchanged. Together, these data provide new evidence for the efficacy of low-dose statin administration to improve locomotor muscle microvascular reactivity in patients with HFpEF, which may be due, in part, to a diminution in oxidative stress.
 Cardiac & Cardiovascular Systems Cardiovascular System & Cardiology Life Sciences & Biomedicine Peripheral Vascular Disease Physiology Science & Technology

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