Journal article
Statin use and delayed onset of Huntington's disease
Movement disorders, Vol.34(2), pp.281-285
02/2019
DOI: 10.1002/mds.27591
PMID: 30576007
Abstract
There is evidence to suggest that 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase inhibitors (statins) may be beneficial in Huntington's disease (HD).
This study aimed to determine if statin use was associated with delayed motor diagnosis in participants with premotor HD.
Among premotor HD participants from the Enroll-HD database, statin users were propensity score matched with statin nonusers based on cytosine-adenine-guanine-age product score, cytosine-adenine-guanine repeat length, baseline age, sex, and region. A Cox regression survival analysis compared the annualized hazard ratio (HR) of receiving a motor diagnosis between the 2 groups.
The annualized HR of progressing to an HD motor diagnosis was lower in the statin users (n = 89) when compared with the statin nonusers (n = 89; HR = 0.27 [95% CI 0.18-0.50], P < .0001).
In patients with premotor HD, statin use was associated with a delayed motor diagnosis of HD. Further studies are warranted to investigate if statins would be an effective disease-modifying therapy for HD. © 2018 International Parkinson and Movement Disorder Society.
Details
- Title: Subtitle
- Statin use and delayed onset of Huntington's disease
- Creators
- Jordan L Schultz - University of Iowa, PsychiatryPeg C Nopoulos - University of Iowa, PsychiatryAnnie Killoran - University of Iowa, NeurologyJohn A Kamholz - University of Iowa, Neurology
- Resource Type
- Journal article
- Publication Details
- Movement disorders, Vol.34(2), pp.281-285
- Publisher
- United States
- DOI
- 10.1002/mds.27591
- PMID
- 30576007
- ISSN
- 0885-3185
- eISSN
- 1531-8257
- Language
- English
- Date published
- 02/2019
- Academic Unit
- Neurology; Psychiatry; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Pharmacy Practice and Science
- Record Identifier
- 9984048600302771
Metrics
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